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首页> 外文期刊>Cardiology >Assessment of Biventricular Function by Three-Dimensional Speckle Tracking Echocardiography in Adolescents and Young Adults with Human Immunodeficiency Virus Infection: A Pilot Study
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Assessment of Biventricular Function by Three-Dimensional Speckle Tracking Echocardiography in Adolescents and Young Adults with Human Immunodeficiency Virus Infection: A Pilot Study

机译：三维散斑跟踪超声心动图在人类免疫缺陷病毒感染的青少年和年轻成人中的三维斑点跟踪超声心动图评估 - 试验研究

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Background: The purpose of the study was to assess biventricular parameters of wall deformation with three-dimensional speckle tracking echocardiography (3DSTE) in adolescents and young adults with human immunodeficiency virus (HIV) infection on antiretroviral therapy in order to detect a possible subclinical myocardial dysfunction. Methods: Twenty-one patients aged 12-39 years with HIV, 21 normal controls of the same age and sex, and 21 patients with idiopathic nonischemic dilated cardiomyopathy (DCM) were studied with 3DSTE. All HIV patients were stable in terms of HIV infection, with no history of heart disease or other chronic systemic disease except HIV infection, and were on highly active antiretroviral therapy with good immunological control. Standard echocardiographic measures of left ventricular (LV)-right ventricular (RV) function were assessed. 3D LV global longitudinal strain (GLS), circumferential strain, radial strain, and LV twist were calculated. Global area strain (GAS) was calculated by 3DSTE as percentage variation in surface area defined by the longitudinal and circumferential strain vectors. 3D RV global and free-wall longitudinal strain (FWLS) were obtained. Results: LV GLS and GAS were lower in HIV patients compared to normal controls (p = 0.002, and p = 0.01, respectively). There were no significant differences in LV ejection fractions between the groups. There was a weak positive correlation between LV GLS and age (r = 0.215, p = 0.034) and a weak negative correlation between LV GLS and nadir-CD4 T-cells count (r = 0.198, p = 0.043). DCM patients had more marked and widespread reduction in LV GLS and GAS compared to controls (p < 0.001), whereas in HIV patients LV strain impairment (p < 0.05) was more localized in basal and apical regions. RV FWLS was significantly reduced in HIV patients when compared with the control group (p = 0.03). No patient had pulmonary systolic pressure higher than 35 mm Hg. Conclusions: 3DSTE may help to identify HIV patients at high cardiovascular risk allowing early detection of biventricular dysfunction in the presence of normal LV ejection fraction and in the absence of pulmonary hypertension. LV strain impairment in HIV patients is less prominent and widespread compared to DCM patients.
机译：背景：该研究的目的是评估与人类免疫缺陷病毒（HIV）感染的青少年和年轻成人的三维斑点跟踪超声心动图（3DSTE）对抗逆转录病毒治疗的青少年散斑跟踪超声心动图（3DSTE）的壁变形的五维曲目，以检测可能的亚临床心肌功能障碍。方法：使用3DSTE研究了21例患有12-39岁的患者12-39岁，21例同龄和性别的正常对照，以及21例特发性无际患病患者（DCM）。所有HIV患者在艾滋病毒感染方面都是稳定的，除了HIV感染外，没有心脏病或其他慢性全身疾病的历史，并在高度活跃的抗逆转录病毒治疗，具有良好的免疫控制。评估左心室（LV） - 术术（RV）功能的标准超声心动图测量。三维LV全局纵向应变（GLS），周向应变，径向菌株和LV捻度。通过3DSTE计算全局区域应变（气体），作为由纵向和周向应变向量限定的表面积的百分比变化。获得3D RV全球和自由墙纵向应变（FWL）。结果：与正常对照相比，HIV患者的LV GLS和气体降低（P = 0.002，分别为P = 0.01）。组之间的LV喷射分数没有显着差异。 LV GLS和年龄（r = 0.215，p = 0.034）之间存在弱的正相关性，LV GL和Nadir-CD4 T细胞计数（r = 0.198，p = 0.043）之间的弱负相关性。与对照组（P <0.001）相比，DCM患者在LV GLS和天然气中具有更大明显和广泛的降低（P <0.001），而在HIV患者中，LV应变损伤（P <0.05）在基础和顶端区域中更为局部。与对照组相比，HIV患者的RV FWL显着降低（P = 0.03）。没有患者具有高于35mm Hg的肺限脉压力。结论：3DSTE可能有助于以高血管造型风险鉴定HIV患者，允许早期检测正常的LV喷射分数和肺动脉高压的存在。与DCM患者相比，HIV患者的LV应变损伤较小，普遍存在。

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