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首页> 外文期刊>Cardiology >Impact of Accumulated Serum Uric Acid on Coronary Culprit Lesion Morphology Determined by Optical Coherence Tomography and Cardiac Outcomes in Patients with Acute Coronary Syndrome
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Impact of Accumulated Serum Uric Acid on Coronary Culprit Lesion Morphology Determined by Optical Coherence Tomography and Cardiac Outcomes in Patients with Acute Coronary Syndrome

机译：急性冠状动脉综合征患者光学相干断层扫描和心脏蛋白患者冠状动脉冠状动脉抑菌病变形态对急性冠状动脉综合征患者的影响

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Objectives: We aimed to examine the relations of very high levels of serum uric acid (sUA) with features of culprit lesion plaque morphology determined by optical coherence tomography (OCT) and adverse clinical outcomes in patients with acute coronary syndrome (ACS). Methods: We retrospectively compared ACS patients according to sUA levels of >8.0 mg/dL (n = 169), 7.1-8.0 mg/dL (n = 163), 6.1-7.0 mg/dL (n = 259), and = 6.0 mg/dL (n = 717). Angiography and OCT findings were analyzed in patients with preintervention OCT and the 4 sUA groups (>8.0 mg/dL, n = 61; 7.1-8.0 mg/dL, n = 72; 6.1-7.0 mg/dL, n = 131; and = 6.0 mg/dL, n = 348) were compared. Results: Cardiogenic shock was more prevalent in ACS patients with sUA > 8.0 mg/dL (22% vs. 19% vs. 10% vs. 6%, p 8.0 mg/dL (67% vs. 47% vs. 56% vs. 45%, p = 0.027). At the 2-year follow-up, Kaplan-Meier estimates showed higher cardiac mortality in patients with sUA > 8.0 mg/dL (25% vs. 12% vs. 5% vs. 5%, p 8.0 mg/dL showed a 4.5-fold increased risk in 2-year cardiac death by multivariate Cox proportional hazard analysis (hazard ratio 4.54, 95% confidence interval 2.98-6.91; p 8.0 mg/dL are the primary predictor of 2-year cardiac mortality and could partly be caused by adverse effects of accumulated sUA on plaque morphology in patients with ACS. (C) 2019 S. Karger AG, Basel
机译：目的：我们旨在研究通过光学相干断层扫描（OCT）和急性冠状动脉综合征（ACS）患者的不良临床结果确定的尖锐病变斑块形态的特征的血清尿酸（SUA）的关系。方法：我们回顾性地比较了ACS患者，根据SUA水平> 8.0mg / dL（n = 169），7.1-8.0mg / dl（n = 163），6.1-7.0mg / dl（n = 259），= 6.0 mg / dl（n = 717）。血管造影和OCT调查结果分析了患者的患者，患者（> 8.0mg / d1，n = 61; 7.1-8.0mg / dl，n = 72; 6.1-7.0mg / dl，n = 131;和比较= 6.0mg / dl，n = 348）。结果：SUA> 8.0mg / dL的ACS患者中的血管生成休克更普遍（22％对19％vs.10％vs.6％，p 8.0mg / dl（67％与47％对56％Vs. 。45％，p = 0.027）。在2年的随访中，Kaplan-Meier估计显示Sua> 8.0mg / dl患者的心脏死亡率较高（25％与12％与5％vs.5％ ，P 8.0 Mg / DL通过多元COX比例危害分析（危险比4.54,95％置信区间2.98-6.91; P 8.0 Mg / DL是2-年心脏病死亡率，可以部分地由积累的SUA对ACS患者斑块形态的不利影响造成的。（c）2019年2019年S. Karger AG，巴塞尔

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