Imaging of Myocardial Fibrosis and Its Functional Correlates in Aortic Stenosis: A Review and Clinical Potential

Katbeh Asim; Ondrus Tomas; Barbato Emanuele; Galderisi Maurizio; Trimarco Bruno; Van Camp Guy; Vanderheyden Marc; Penicka Martin

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Imaging of Myocardial Fibrosis and Its Functional Correlates in Aortic Stenosis: A Review and Clinical Potential

机译：心肌纤维化的成像及其主动脉狭窄中的功能相关性：综述和临床潜力

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Patients with severe aortic stenosis (AS) show progressive fibrotic changes in the myocardium, which may impair cardiac function and patient outcomes even after successful aortic valve replacement. Detection of patients who need an early operation remains a diagnostic challenge as myocardial functional changes may be subtle. In recent years, speckle tracking echocardiography (STE) and cardiac magnetic resonance mapping have been shown to provide complementary information for the assessment of left ventricular mechanics and identification of subtle damage by focal or diffuse myocardial fibrosis, respectively. Little is known, however, about how focal and diffuse myocardial fibrosis occurring in severe AS are related to measurable functional changes by echocardiography and to which extent both parameters have prognostic and diagnostic value. The aims of this review are to discuss the occurrence of focal and diffuse myocardial fibrosis in patients with severe AS and to explore their relation with myocardial function, determined by STE, as well as the prognostic and diagnostic potential of both parameters. (c) 2018 S. Karger AG, Basel

机译：严重主动脉狭窄（AS）的患者显示心肌的渐进式纤维化变化，即使在成功的主动脉瓣置换后，也可能损害心脏功能和患者结果。检测需要早期操作的患者仍然是诊断挑战，因为心肌功能变化可能是微妙的。近年来，已经证明了散斑跟踪超声心动图（STE）和心脏磁共振映射分别提供了评估左心室力学的互补信息，并分别通过焦点或弥漫性心肌纤维化进行微妙损伤。然而，众所周知，关于如何严重发生的焦点和弥漫性心肌纤维化与超声心动图的可测量功能变化有关，以及在哪个参数具有预后和诊断价值的情况下。本综述的目的是讨论严重的患者的局灶性和弥漫性心肌纤维化的发生，并通过STE确定的患者和探索其与心肌功能的关系，以及两个参数的预后和诊断潜力。（c）2018年S. Karger AG，巴塞尔

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《Cardiology》 |2018年第3期|共9页
作者
Katbeh Asim; Ondrus Tomas; Barbato Emanuele; Galderisi Maurizio; Trimarco Bruno; Van Camp Guy; Vanderheyden Marc; Penicka Martin;
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作者单位

OLV Clin Cardiovasc Ctr Aalst Moorselbaan 164 BE-9300 Aalst Belgium;

OLV Clin Cardiovasc Ctr Aalst Moorselbaan 164 BE-9300 Aalst Belgium;

OLV Clin Cardiovasc Ctr Aalst Moorselbaan 164 BE-9300 Aalst Belgium;

Univ Naples Federico II Dept Adv Biomed Sci Naples Italy;

Univ Naples Federico II Dept Adv Biomed Sci Naples Italy;

OLV Clin Cardiovasc Ctr Aalst Moorselbaan 164 BE-9300 Aalst Belgium;

OLV Clin Cardiovasc Ctr Aalst Moorselbaan 164 BE-9300 Aalst Belgium;

OLV Clin Cardiovasc Ctr Aalst Moorselbaan 164 BE-9300 Aalst Belgium;

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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Aortic stenosis; Cardiac magnetic resonance; Myocardial fibrosis; Speckle tracking echocardiography; Left ventricular function;

机译：主动脉狭窄;心肌共振;心肌纤维化;斑点跟踪超声心动图;左心室功能;

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1. Imaging of Myocardial Fibrosis and Its Functional Correlates in Aortic Stenosis: A Review and Clinical Potential [J] . Katbeh Asim, Ondrus Tomas, Barbato Emanuele, Cardiology . 2018,第3期

机译：心肌纤维化的成像及其主动脉狭窄中的功能相关性：综述和临床潜力
2. TCT-454 Myocardial Fibrosis Imaging by Speckle Tracking Echocardiography Improves Risk Stratification in Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement [J] . Ahmad Manshad, Mohamad Hemu, Fatima Ballout, Journal of the American College of Cardiology . 2018,第13期

机译：TCT-454散斑跟踪超声心动图的心肌纤维化成像提高了经截面主动脉瓣置换后严重主动脉狭窄的风险分层
3. Myocardial deformation imaging by two-dimensional speckle-tracking echocardiography in comparison to late gadolinium enhancement cardiac magnetic resonance for analysis of myocardial fibrosis in severe aortic stenosis. [J] . Rainer Hoffmann, Ertunc Altiok, Zvi Friedman, The American Journal of Cardiology . 2014,第7期

机译：通过二维散斑跟踪超声心动图与晚期g增强心脏磁共振的比较来分析心肌变形，以分析严重主动脉狭窄中的心肌纤维化。
4. From Clinical Imaging to Patient-Specific Computational Model: Rapid Adaptation of the Living Heart Human Model to a Case of Aortic Stenosis [C] . Andrew D. Wisneski, Salvatore Cutugno, Ashley Stroh, International Conference on Functional Imaging and Modeling of the Heart . 2021

机译：从临床成像到患者特定的计算模型：将活心脏人体模型快速适应主动脉狭窄的情况
5. Assessment of native aortic stenosis hemodynamics and clinical evaluation methods using steady state computational fluid dynamics and computed tomography-derived geometry. [D] . Traeger, Brad James. 2012

机译：评估自然主动脉瓣狭窄血流动力学和临床评估方法，使用稳态计算流体动力学和计算机断层扫描衍生的几何形状。
6. Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis [O] . Michael Gotzmann, Susanne Grabbe, Dominik Schöne, 2018

机译：严重主动脉瓣狭窄血流动力学亚群的体质性质和心肌纤维化改变与临床表型相关
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Imaging of Myocardial Fibrosis and Its Functional Correlates in Aortic Stenosis: A Review and Clinical Potential

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