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首页> 外文期刊>Cardiology in review >Searching for the Genetic Determinants of Peripheral Arterial Disease: A Review of the Literature and Future Directions.
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Searching for the Genetic Determinants of Peripheral Arterial Disease: A Review of the Literature and Future Directions.

机译：寻找外周血动脉疾病的遗传决定因素：对文学和未来方向的审查。

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摘要

Peripheral arterial disease (PAD) is a significant but under-recognized disease that is poorly understood despite population-scale genetic studies. To address this morbid disease, clinicians need additional tools to identify, prevent, and treat patients at risk for PAD. Genetic studies of coronary artery disease have yielded promising results for clinical application, which have thus far been lacking in PAD. In this article, we review recent findings, discuss limitations, and propose future directions of genomic study and clinical application. However, despite many studies, we still lack definitive genetic markers for PAD. This can be attributed to the heterogeneity of PAD's pathogenesis and clinical manifestations, as well as inconsistencies in study methodologies, limitations of current genetic assessment techniques, incompletely comprehended molecular pathophysiology, and confounding generalized atherosclerotic risk factors. The goals of this review are to evaluate the limitations of our current genetic knowledge of PAD and to propose approaches to expedite the identification of valuable markers of PAD.
机译：尽管人口规模遗传学研究，外周动脉疾病（垫）是一种重要但不公之症疾病，但仍然很清楚。为了解决这种病态疾病，临床医生需要额外的工具来识别，预防和治疗患者的患者。冠状动脉疾病的遗传学研究对临床应用产生了有希望的结果，这对于垫子缺乏缺乏。在本文中，我们审查了最近的调查结果，讨论了局限性，并提出了未来的基因组研究和临床应用方向。然而，尽管很多研究，我们仍然缺乏垫的明确遗传标记。这可归因于垫的发病机制和临床表现的异质性，以及研究方法的不一致，当前遗传评估技术的限制，不完全理解的分子病理生理学和混淆的广义动脉粥样硬化危险因素。本综述的目标是评估我们目前对垫的遗传知识并提出方法来加快识别垫的有价值标记的方法的限制。

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  • 来源
    《Cardiology in review》 |2019年第3期|共8页
  • 作者

    Dean L Kellogg; Susan Fisher-Hoch; Joseph B McCormick; Anand Prasad;

  • 作者单位

    From the Division of Cardiology Department of Medicine University of Texas Health Science Center;

    Department of Epidemiology Human Genetics &

    Environmental Sciences University of Texas-Houston;

    Department of Epidemiology Human Genetics &

    Environmental Sciences University of Texas-Houston;

    From the Division of Cardiology Department of Medicine University of Texas Health Science Center;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 心脏、血管（循环系）疾病;
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