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首页> 外文期刊>Biological Cybernetics: Communication and Control in Organisms and Automata: = Nachrichtenubertragung, Nachrichtenverarbeitung, Steuerung und Regelung in Organismen und in Automaten >Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation
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Cortical stimulation in aphasia following ischemic stroke: toward model-guided electrical neuromodulation

机译：缺血性脑卒中后性腺的皮质刺激：朝向模型引导电神经调节

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The aim of this paper is to integrate different bodies of research including brain traveling waves, brain neuromodulation, neural field modeling and post-stroke language disorders in order to explore the opportunity of implementing model-guided, cortical neuromodulation for the treatment of post-stroke aphasia. Worldwide according to WHO, strokes are the second leading cause of death and the third leading cause of disability. In ischemic stroke, there is not enough blood supply to provide enough oxygen and nutrients to parts of the brain, while in hemorrhagic stroke, there is bleeding within the enclosed cranial cavity. The present paper focuses on ischemic stroke. We first review accumulating observations of traveling waves occurring spontaneously or triggered by external stimuli in healthy subjects as well as in patients with brain disorders. We examine the putative functions of these waves and focus on post-stroke aphasia observed when brain language networks become fragmented and/or partly silent, thus perturbing the progression of traveling waves across perilesional areas. Secondly, we focus on a simplified model based on the current literature in the field and describe cortical traveling wave dynamics and their modulation. This model uses a biophysically realistic integro-differential equation describing spatially distributed and synaptically coupled neural networks producing traveling wave solutions. The model is used to calculate wave parameters (speed, amplitude and/or frequency) and to guide the reconstruction of the perturbed wave. A stimulation term is included in the model to restore wave propagation to a reasonably good level. Thirdly, we examine various issues related to the implementation model-guided neuromodulation in the treatment of post-stroke aphasia given that closed-loop invasive brain stimulation studies have recently produced encouraging results. Finally, we suggest that modulating traveling waves by acting selectively and dynamically across space and time to facilitate wave propagation is a promising therapeutic strategy especially at a time when a new generation of closed-loop cortical stimulation systems is about to arrive on the market.
机译：本文的目的是将不同的研究机构整合，包括脑旅行波，脑神经调节，神经场建模和中风后语言障碍，以探索实施模型引导的皮质神经调节的机会，用于治疗卒中后卒中失语症。全世界根据世卫组织，中风是死亡的第二个主要原因，以及第三个担任残疾原因。在缺血性卒中中，没有足够的血液供应来为脑部的部分提供足够的氧气和营养，而在出血性中风中，封闭的颅腔内出现出血。本文侧重于缺血性卒中。我们首先审查积累的行驶波的观察，或者在健康受试者中的外部刺激以及脑疾病的患者中进行外部刺激。我们检查这些波的推定功能，并专注于脑语语言网络分散和/或部分沉默时观察到的后卒中性失语症，从而扰乱了跨越围绕围绕的行驶波的进展。其次，我们专注于基于现场文献的简化模型，并描述了皮质行程波动动态及其调制。该模型使用了一种生物物理学的积分微分方程，描述了生产行波解决方案的空间分布式和突触耦合神经网络。该模型用于计算波参数（速度，幅度和/或频率）并引导扰动波的重建。刺激项包括在模型中，以将波浪传播恢复到合理良好的水平。第三，鉴于闭环侵袭性脑刺激研究最近产生令人鼓舞的结果，我们研究了与实施模型引导的神经调节相关的各种问题。最后，我们建议通过选择性地和动态地跨空间和动态地调制行驶波，以便于波传播是一种有前途的治疗策略，特别是在新一代闭环皮质刺激系统即将到达市场时的时间。

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