Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells.

Tseng YL; Wu MH; Yang HC; Wang CY; Lin CF

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Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells.

机译：自分泌IL-6调节胸腺上皮细胞中GRO-α的产生。

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Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody array and ELISA, in addition to IL-8 and MCP-1, growth-related oncogene-alpha (GRO-alpha) was subsequently expressed after IL-6 production. Either IL-6 or GRO-alpha was time-dependently and strongly expressed in medium with and without serum. Neutralizing IL-6 significantly reduced GRO-alpha production. Inhibiting Janus kinase 2 (Jak2) spontaneously blocked GRO-alpha production with or without IL-6 stimulation. We conclude that primary human thymic epithelial cells produce GRO-alpha and that its expression is regulated primarily by autocrine IL-6 and IL-6-activated Jak2 signaling.

机译：胸腺白细胞介素6（IL-6）主要由胸腺上皮细胞产生，是胸腺T细胞生长和分化的重要细胞因子。在本研究中，我们研究了自分泌IL-6对人胸腺上皮细胞原代培养物中细胞因子的影响。除了IL-8和MCP-1外，还使用抗体阵列和ELISA法在IL-6产生后表达与生长相关的癌基因-α（GRO-α）。 IL-6或GRO-alpha随时间变化，在有血清和无血清的培养基中均强烈表达。中和IL-6会大大降低GRO-α的产生。抑制Janus激酶2（Jak2）自发地阻断具有或不具有IL-6刺激的GRO-α的产生。我们得出结论，原代人胸腺上皮细胞产生GRO-alpha，其表达主要受自分泌IL-6和IL-6激活的Jak2信号传导调控。

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《Cytokine》 |2010年第2期|共7页
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Tseng YL; Wu MH; Yang HC; Wang CY; Lin CF;
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中图分类细胞生物学;
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1. Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells. [J] . Tseng YL, Wu MH, Yang HC, Cytokine . 2010,第2期

机译：自分泌IL-6调节胸腺上皮细胞中GRO-α的产生。
2. Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha), IL-1 beta, and IL-6 in human thymic epithelial cells at a post-transcriptional level. [J] . P T Le, S Lazorick, L P Whichard, The Journal of Experomental Medicine . 1991,第5期

机译：调节人胸腺细胞因子的产生：表皮生长因子和转化生长因子α调节转录后的人胸腺上皮细胞中白介素1 alpha（IL-1 alpha），IL-1 beta和IL-6 mRNA水平水平。
3. Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells. [J] . Xiao W, Hodge DR, Wang L, The Prostate . 2004,第4期

机译：核因子NFkappaB和CCAT /增强子结合蛋白β（C / EBP-beta）之间的协同功能调节自分泌人类前列腺癌细胞中的IL-6启动子。
4. Effect of miR223 on production of IL-1β and IL-6 in gingival epithelial cells [C] . Ying Wen, Binjie Liu International Conference on Biological Information and Biomedical Engineering . 2019

机译：miR223对牙龈上皮细胞IL-1β和IL-6产生的影响
5. Autocrine and Paracrine Signaling Regulates Breast Cancer Stem Cells and Epithelial-Mesenchymal Transition in Inflammatory Breast Cancer [D] . Valeta, Amanda. 2016

机译：自分泌和旁碱基信号调节炎症乳腺癌中的乳腺癌干细胞和上皮 - 间充质转换
6. Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor alpha regulate mRNA levels of interleukin 1 alpha (IL-1 alpha) IL-1 beta and IL-6 in human thymic epithelial cells at a post-transcriptional level [O] . 1991

机译：调节人胸腺细胞因子的产生：表皮生长因子和转化生长因子α调节转录后的人胸腺上皮细胞中白介素1 alpha（IL-1 alpha）IL-1 beta和IL-6 mRNA水平水平
7. p38 MAPK is a critical regulator of the constitutive and the beta4 integrin-regulated expression of IL-6 in human normal thymic epithelial cells. [O] . Fabrizio Mainiero, Michaela Colombara, Valeria Antonini, 2003

机译：p38 MAPK是人类正常胸腺上皮细胞中IL-6的组成型和β4整合素调节表达的关键调节剂。

Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells.

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