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首页> 外文期刊>Cytokine >Transcription factor Ets-1 in cytokine and chemokine gene regulation.
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Transcription factor Ets-1 in cytokine and chemokine gene regulation.

机译:转录因子Ets-1在细胞因子和趋化因子基因调控中的作用。

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摘要

Ets-1 is a transcription factor that is highly expressed within lymphoid cells, where it is known to control their differentiation, survival and proliferation. Ets-1 is also expressed in other cell types and can be further induced by a variety of stimuli. Accumulating evidence points to an important role for Ets-1 in regulating the differentiation of T helper cell subsets, cytotoxic T cells, B cells and other cell types. Ets-1 also directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. In this review, we summarize the known roles for Ets-1 in regulating the differentiation of immune cells and other cell types. Furthermore, we review in detail the current understanding of Ets-1 regulation of cytokine and chemokine expression and how this may relate to the biological roles of Ets-1 in regulating immunity as well as in cancer progression.
机译:Ets-1是在淋巴样细胞中高度表达的转录因子,已知它可以控制它们的分化,存活和增殖。 Ets-1也在其他细胞类型中表达,并且可以被多种刺激进一步诱导。越来越多的证据表明Ets-1在调节T辅助细胞亚群,细胞毒性T细胞,B细胞和其他细胞类型的分化中起着重要作用。 Ets-1在多种不同的细胞环境中也直接控制细胞因子和趋化因子基因的表达。在这篇综述中,我们总结了Ets-1在调节免疫细胞和其他细胞类型分化中的已知作用。此外,我们详细审查了目前对Ets-1调节细胞因子和趋化因子表达的理解,以及这可能与Ets-1在调节免疫以及癌症进展中的生物学作用有关。

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