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首页> 外文期刊>Cytokine >TIR-containing adaptors in Toll-like receptor signalling.
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TIR-containing adaptors in Toll-like receptor signalling.

机译：Toll样受体信号传导中的TIR适配器。

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摘要

While the Toll-like receptors (TLRs) are responsible for the recognition and response to pathogen ligands, increasing evidence suggests that the family of five cytosolic Toll/IL-1 receptor (TIR) adaptor proteins also play a crucial role in the specificity of the response. Genetic studies in mice, and increasingly in human polymorphic populations, have given us a greater understanding the role these adaptors play in orchestrating and coordinating the multifaceted immune response to multiple exogenous threats. Importantly, with growing evidence of the critical role TLRs play in responses to host danger signals and autoimmune disease, a more comprehensive understanding and appreciation of the role these adaptors play in disease progression may provide future targets for therapeutic intervention in human disease. Importantly, growing evidence supports the concept of pathway specific and inflammatory control by a better understanding of how these adaptors interact with other signalling mediators, where they localise within the cell and the inflammatory programs they initiate as a way of manipulating immune responses. This review deals with our current understanding of these TIR-containing adaptor proteins and how mutagenesis of specific residues and domains has increased our knowledge of their function in TLR immune responses.
机译：尽管Toll样受体（TLR）负责识别和响应病原体配体，但越来越多的证据表明，五个胞质Toll / IL-1受体（TIR）衔接子蛋白家族在它们的特异性中也起着至关重要的作用。响应。在小鼠以及越来越多的人类多态性种群中进行的遗传研究使我们对这些衔接子在协调和协调对多种外源性威胁的多方面免疫反应中所起的作用有了更深入的了解。重要的是，随着越来越多的证据表明TLR在应对宿主危险信号和自身免疫疾病中起着关键作用，对这些衔接子在疾病进展中所起作用的更全面的理解和认识可能会为人类疾病的治疗干预提供未来的目标。重要的是，越来越多的证据通过更好地了解这些衔接子如何与其他信号传导介质相互作用而支持了通路特异性和炎症控制的概念，这些信号转导介质位于细胞内，并以操纵免疫反应的方式引发炎症程序。这项审查涉及我们目前对这些包含TIR的衔接蛋白的理解，以及对特定残基和结构域的诱变如何增加我们对它们在TLR免疫反应中的功能的了解。

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