Initial experience of a large, self‐expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters’ registry

Dowling Cameron; Firoozi Sami; Doyle Niamh; Blackman Daniel J.; Malkin Christopher J.; Cunnington Michael S.; Saraf Smriti; Buch Mamta H.; Levy Richard; Chowdhary Saqib; Spence Mark S.; Manoharan Ganesh; Owens Colum G.; Brennan Paul F.; Roberts David; More Ranjit; Wiper Andrew; Abdelaziz Hesham K.; Mylotte Darren; Neylon Antoinette; Martin Niamh; Mercanti Federico; Dorman Stephen; Panoulas Vasileios; Dalby Miles; Kashyap Mavin N.; Kabir Tito; Kovac Jan; Kontoprias Kosmas; Malik Iqbal S.; Ghada Mikhail W.; Sen Sayan; Ruparelia Neil; Demir Ozan M.; Frame Angela; Uren Neal G.; Anderson Richard; Rajathurai Thirumaran; Tapp Luke; Deegan Lauren; Grech Ever; Hall Ian; Neville Melanie; Rampat Rajiv; Hildick‐Smith David; Mullen Michael; Kennon Simon; Chandrala Pavan; Doshi Sagar; Brecker Stephen J.

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Initial experience of a large, self‐expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters’ registry

机译：初始经验大型，自拓，完全可重新接受的经齿轮转膜管主动脉瓣：英国＆爱尔兰植入机的注册表

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Abstract Objectives : The UK & Ireland Implanters’ registry is a multicenter registry which reports on real‐world experience with novel transcatheter heart valves. Background : The 34?mm Evolut R transcatheter aortic valve is a self‐expanding and fully recapturable transcatheter aortic valve, designed to treat patients with a large aortic annulus. Methods : Between January 2017 and April 2018, clinical, procedural and 30‐day outcome data were prospectively collected from all patients receiving the 34?mm Evolut R valve across 17 participating centers in the United Kingdom and Ireland. The primary efficacy outcome was the Valve Academic Research Consortium‐2(VARC‐2)‐defined endpoint of device success. The primary safety outcome was the VARC‐2‐defined composite endpoint of early safety at 30?days. Results : A total of 217 patients underwent attempted implant. Mean age was 79.5?±?8.8 years and Society of Thoracic Surgeons Predicted Risk of Mortality Score 5.2%?±?3.4%. Iliofemoral access was used in 91.2% of patients. Device success was 79.7%. Mean gradient was 7.0?±?4.6 mmHg and effective orifice area 2.0?±?0.6 cm 2 . Paravalvular regurgitation was more than mild in 7.2%. A new permanent pacemaker was implanted in 15.7%. Early safety was demonstrated in 91.2%. At 30?days, all‐cause mortality was 3.2%, stroke 3.7%, and major vascular complication 2.3%. Conclusions : Real‐world experience of the 34?mm Evolut R transcatheter aortic valve demonstrated acceptable procedural success, safety, valve function, and incidence of new permanent pacemaker implantation.

机译：摘要目标：英国＆amp;爱尔兰植入机构的注册表是一款多中心注册表，报告了具有新型经截面心阀的真实体验。背景：34？MM Evolut R经变形管主动脉瓣是一种自膨胀和完全可循环的经螺旋管主动脉瓣，旨在治疗具有大主动脉环的患者。方法：2018年1月至2018年4月，临床，程序和30天的结果数据从英国和爱尔兰的17名参与中心接受34岁的所有患者预先收集所有患者。主要疗效结果是阀门学术研究联盟-2（VARC-2） - 设备成功的终点。主要的安全结果是varc-2定义的综合统计终点，早期安全30？天。结果：共有217名患者经历了植入植入。平均年龄为79.5？±8.8岁，胸外科医生的社会预测死亡率的风险为5.2％？±3.4％。 iliofoMoral接入用于91.2％的患者。设备成功为79.7％。平均梯度为7.0？±4.6 mmHg和有效的孔口区域2.0？±0.6cm 2。静脉瓣膜流动超过7.2％。新的永久性起搏器植入15.7％。早期安全性得到了91.2％。在30个？天，全因死亡率为3.2％，中风3.7％，主要血管并发症2.3％。结论：34毫升evolut r经变形管主动脉瓣的现实世界经验表明了可接受的程序成功，安全，阀功能和新的永久起搏器植入的发病率。

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《Catheterization and cardiovascular interventions: Official journal of the Society for Cardiac Angiography & Interventions》 |2019年第4期|共7页
作者
Dowling Cameron; Firoozi Sami; Doyle Niamh; Blackman Daniel J.; Malkin Christopher J.; Cunnington Michael S.; Saraf Smriti; Buch Mamta H.; Levy Richard; Chowdhary Saqib; Spence Mark S.; Manoharan Ganesh; Owens Colum G.; Brennan Paul F.; Roberts David; More Ranjit; Wiper Andrew; Abdelaziz Hesham K.; Mylotte Darren; Neylon Antoinette; Martin Niamh; Mercanti Federico; Dorman Stephen; Panoulas Vasileios; Dalby Miles; Kashyap Mavin N.; Kabir Tito; Kovac Jan; Kontoprias Kosmas; Malik Iqbal S.; Ghada Mikhail W.; Sen Sayan; Ruparelia Neil; Demir Ozan M.; Frame Angela; Uren Neal G.; Anderson Richard; Rajathurai Thirumaran; Tapp Luke; Deegan Lauren; Grech Ever; Hall Ian; Neville Melanie; Rampat Rajiv; Hildick‐Smith David; Mullen Michael; Kennon Simon; Chandrala Pavan; Doshi Sagar; Brecker Stephen J.;
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作者单位

Cardiology Clinical Academic Group St. George's University of London and St. George's University;

Cardiology Clinical Academic Group St. George's University of London and St. George's University;

Cardiology Clinical Academic Group St. George's University of London and St. George's University;

Department of CardiologyLeeds General InfirmaryLeeds United Kingdom;

Department of CardiologyLeeds General InfirmaryLeeds United Kingdom;

Department of CardiologyLeeds General InfirmaryLeeds United Kingdom;

Department of CardiologyLeeds General InfirmaryLeeds United Kingdom;

Department of CardiologyManchester University NHS Foundation TrustManchester United Kingdom;

Department of CardiologyManchester University NHS Foundation TrustManchester United Kingdom;

Department of CardiologyManchester University NHS Foundation TrustManchester United Kingdom;

Belfast Heart CentreRoyal Victoria HospitalBelfast United Kingdom;

Belfast Heart CentreRoyal Victoria HospitalBelfast United Kingdom;

Belfast Heart CentreRoyal Victoria HospitalBelfast United Kingdom;

Belfast Heart CentreRoyal Victoria HospitalBelfast United Kingdom;

Lancashire Cardiac CentreBlackpool Victoria HospitalBlackpool United Kingdom;

Lancashire Cardiac CentreBlackpool Victoria HospitalBlackpool United Kingdom;

Lancashire Cardiac CentreBlackpool Victoria HospitalBlackpool United Kingdom;

Lancashire Cardiac CentreBlackpool Victoria HospitalBlackpool United Kingdom;

Department of CardiologyUniversity Hospital GalwayGalway Ireland;

Department of CardiologyUniversity Hospital GalwayGalway Ireland;

Department of CardiologyUniversity Hospital GalwayGalway Ireland;

Department of CardiologyUniversity Hospital GalwayGalway Ireland;

Department of CardiologyBristol Heart InstituteBristol United Kingdom;

Department of CardiologyHarefield HospitalLondon United Kingdom;

Department of CardiologyHarefield HospitalLondon United Kingdom;

Department of CardiologyHarefield HospitalLondon United Kingdom;

Department of CardiologyHarefield HospitalLondon United Kingdom;

Biomedical Research UnitUniversity of LeicesterLeicester United Kingdom;

Biomedical Research UnitUniversity of LeicesterLeicester United Kingdom;

Department of CardiologyHammersmith Hospital Imperial College Healthcare NHS TrustLondon United;

Department of CardiologyHammersmith Hospital Imperial College Healthcare NHS TrustLondon United;

Department of CardiologyHammersmith Hospital Imperial College Healthcare NHS TrustLondon United;

Department of CardiologyHammersmith Hospital Imperial College Healthcare NHS TrustLondon United;

Department of CardiologyHammersmith Hospital Imperial College Healthcare NHS TrustLondon United;

Department of CardiologyHammersmith Hospital Imperial College Healthcare NHS TrustLondon United;

Edinburgh Heart CentreRoyal Infirmary of EdinburghEdinburgh United Kingdom;

Department of CardiologyUniversity Hospital of WalesCardiff United Kingdom;

Department of CardiologyUniversity HospitalCoventry United Kingdom;

Department of CardiologyUniversity HospitalCoventry United Kingdom;

Department of CardiologyUniversity HospitalCoventry United Kingdom;

Department of CardiologyNorthern General HospitalSheffield United Kingdom;

Department of CardiologyNorthern General HospitalSheffield United Kingdom;

Department of CardiologyNorthern General HospitalSheffield United Kingdom;

Department of CardiologyRoyal Sussex County HospitalBrighton United Kingdom;

Department of CardiologyRoyal Sussex County HospitalBrighton United Kingdom;

Barts Heart CentreSt. Bartholomew's HospitalLondon United Kingdom;

Barts Heart CentreSt. Bartholomew's HospitalLondon United Kingdom;

Barts Heart CentreSt. Bartholomew's HospitalLondon United Kingdom;

Department of CardiologyQueen Elizabeth HospitalBirmingham United Kingdom;

Cardiology Clinical Academic Group St. George's University of London and St. George's University;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
aortic stenosis; self‐expanding transcatheter aortic valve; transcatheter aortic valve replacement;

机译：主动脉狭窄;自膨胀经变形管主动脉瓣;经沟管主动脉瓣更换;

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专利

1. Initial experience of a large, self‐expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters’ registry [J] . Dowling Cameron, Firoozi Sami, Doyle Niamh, Catheterization and cardiovascular interventions: Official journal of the Society for Cardiac Angiography & Interventions . 2019,第4期

机译：初始经验大型，自拓，完全可重新接受的经齿轮转膜管主动脉瓣：英国＆爱尔兰植入机的注册表
2. Initial Experience of a Second-Generation Self-Expanding Transcatheter Aortic Valve The UK & Ireland Evolut R Implanters' Registry [J] . Kalra Sundeep S., Firoozi Sami, Yeh James, JACC. Cardiovascular interventions . 2017,第3期

机译：第二代自膨胀经齿轮管主动脉瓣的初步体验英国＆爱尔兰Evolut R Inclanters的注册表
3. Initial experience of a self‐expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry [J] . Catheterization and cardiovascular interventions: Official journal of the Society for Cardiac Angiography & Interventions . 2020,第7期

机译：具有外心包包装的自膨胀转膜管主动脉瓣的初步体验：英国和爱尔兰植入机构的注册表
4. Automated Detection of Aortic Root Landmarks in Preprocedure CT Angiography Images for Transcatheter Aortic Valve Implantation Patients [C] . Mustafa Elattar, Esther Wiegerinck, Floortje van Kesteren, International conference on image analysis and recognition . 2015

机译：导管前主动脉瓣植入患者术前CT血管造影图像中主动脉根部地标的自动检测
5. The Learning Curve and Annual Procedure Volume Standards for Optimum Outcomes of Transcatheter Aortic Valve Replacement: Findings from an International Registry [D] . Wassef, Anthony. 2018

机译：学习曲线和年度手术体积标准，用于经截管主动脉瓣换乘器的最佳结果：国际登记处的调查结果
6. Balloon Expandable Transcatheter Aortic Valve Implantation in Failing Self-Expandable Transcatheter Valve in Degenerated Surgical Bioprosthesis: Valve-in-Valve-in-Valve Implantation for the Treatment of Early Degenerative Prosthetic Insufficiency [O] . Ahmed Subahi, Rashid Alhusain, Rasikh Ajmal, 2021

机译：气囊可扩展的经变形管主动脉瓣注入在退化外科生物假期中的自膨胀导阀失效：阀内阀门植入治疗早期退行性假体不足
7. Letter by Abbas Regarding Articles, “Balloon-Expandable Versus Self-Expanding Transcatheter Aortic Valve Replacement: A Propensity-Matched Comparison From the FRANCE-TAVI Registry” and “Impact of Sapien 3 Balloon-Expandable Versus Evolut R Self-Expandable Transcatheter Aortic Valve Implantation in Patients With Aortic Stenosis: Data From a Nationwide Analysis” [O] . Amr E. Abbas 2020

机译：ABBAS关于文章的信，“气球 - 可扩展与自扩张经沟管主动脉瓣主动脉瓣更换：与法国-TAVI注册表的倾向匹配比较”和“SAPIEN 3气球扩张的影响与Evolut R自扩张的经透视表主动脉瓣植入在主动脉狭窄的患者中：来自全国范围内的数据“

Initial experience of a large, self‐expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters’ registry

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