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首页> 外文期刊>Catheterization and cardiovascular interventions: Official journal of the Society for Cardiac Angiography & Interventions >Quantitative flow ratio for immediate assessment of nonculprit lesions in patients with ST‐segment elevation myocardial infarction—An iSTEMI substudy
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Quantitative flow ratio for immediate assessment of nonculprit lesions in patients with ST‐segment elevation myocardial infarction—An iSTEMI substudy

机译：定量流动比率，即在ST段抬高患者心肌梗死患者中的非额外评估 - 一种istemi superdy

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Abstract Objectives We evaluated the diagnostic performance of quantitative flow ratio (QFR) assessment of nonculprit lesions (NCLs) based on acute setting angiograms obtained in patients with ST‐segment elevation myocardial infarction (STEMI) with QFR, fractional flow reserve (FFR), and instantaneous wave‐free ratio (iFR) in the staged setting as reference. Background QFR is an angiography‐based approach for the functional evaluation of coronary artery lesions. Methods This was a post‐hoc analysis of the iSTEMI study. NCLs were assessed with iFR in the acute setting and with iFR and FFR at staged (median 13?days) follow‐up. Acute and staged QFR values were computed in a core laboratory based on the coronary angiography recordings. Diagnostic cut‐off values were ≤0.80 for QFR and FFR, and ≤0.89 for iFR. Results Staged iFR and FFR data were available for 146 NCLs in 112 patients in the iSTEMI study. Among these, QFR analysis was feasible in 103 (71%) lesions assessed in the acute setting with a mean QFR value of 0.82 (IQR: 0.73–0.91). Staged QFR, FFR, and iFR were 0.80 (IQR: 0.70–0.90), 0.81 (IQR: 0.71–0.88), and 0.91 (IQR: 0.87–0.96), respectively. Classification agreement of acute and staged QFR was 93% (95%Cl: 87–99). The classification agreement of acute QFR was 84% (95%CI: 76–90) using staged FFR as reference and 74% (95%CI: 65–83) using staged iFR as reference. Conclusions Acute QFR showed a very good diagnostic performance with staged QFR as reference, a good diagnostic performance with staged FFR as reference, and a moderate diagnostic performance with staged iFR as reference.
机译：摘要目的，我们评估了基于在QFR，分数流量储备（FFR）患者中获得的急性定量病变（NCLS）的定量流量比（NCLS）对非额外病变（NCL）评估的诊断性能（QFR）评估分阶段设置中的瞬时波（IFR）作为参考。背景技术QFR是一种基于血管造影的血管造影的方法，用于冠状动脉病变的功能评估。方法这是istemi研究的后期内部分析。使用IFR在急性设定中评估NCLS，并在分阶段（中位数13？天）随访中使用IFR和FFR。基于冠状动脉血管造影记录计算核心实验室中的急性和分阶段的QFR值。 QFR和FFR的诊断截止值≤0.80，IFR的≤0.89。结果IFR和FFR数据可用于112名患者在ISTEMI研究中的146名NCL中。其中，QFR分析在急性设定中评估的103（71％）病变中可行，其平均QFR值为0.82（IQR：0.73-0.91）。分期QFR，FFR和IFR分别为0.80（IQR：0.70-0.90），0.81（IQR：0.71-0.88）和0.91（IQR：0.87-0.96）。急性和分阶段QFR的分类协议为93％（95％CL：87-99）。急性QFR的分类协议是使用分阶段FFR作为参考的84％（95％CI：76-90），其中74％（95％CI：65-83），使用Stage IFR作为参考。结论急性QFR表现出非常好的诊断性能，QFR作为参考，具有良好的诊断性能，具有分阶段的FFR作为参考，以及具有分阶段IFR的中度诊断性能作为参考。

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