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首页> 外文期刊>Cell Host & Microbe >Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites
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Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites

机译：比较异质甘油蛋白谱揭示与疟疾寄生虫适应和发育相关的保守和独特的外观蛋白酶签名

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摘要

Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodiumfalciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive analysis of heterochromatin landscapes across different Plasmodium species, strains, and life cycle stages. Common targets of epigenetic silencing include fast-evolving multi-gene families encoding surface antigens and a small set of conserved HP1-associated genes with regulatory potential. Many P. falciparum heterochromatic genes are marked in a strain-specific manner, increasing the parasite's adaptive capacity. Whereas heterochromatin is strictly maintained during mitotic proliferation of asexual blood stage parasites, substantial heterochromatin reorganization occurs in differentiating gametocytes and appears crucial for the activation of key gametocyte-specific genes and adaptation of erythrocyte remodeling machinery. Collectively, these findings provide a catalog of heterochromatic genes and reveal conserved and specialized features of epigenetic control across the genus Plasmodium.
机译：依赖于旋光素依赖性基因沉默是疟原虫疟疾疟疾疟疾的适应和存活的核心，允许克隆变异基因在人类血液感染过程中表达。通过评估基因组 - 宽的异铬蛋白1（HP1）占用率，我们对不同疟原虫物种，菌株和生命周期阶段进行了综合分析杂种素景观。表观遗传沉默的常见目标包括编码表面抗原的快速发展的多基因家族和具有调节潜力的一小组保守的HP1相关基因。许多P. falciparum异色基因以菌株特异性的方式标记，增加寄生虫的自适应能力。虽然在无性血液阶段寄生虫的有丝分裂增殖期间严格维持异铬胺，但在区分配子细胞中发生了大量的异铬胺重组，并且对激活关键的配子织物特异性基因和红细胞改造机械的适应性至关重要。总的来说，这些发现提供了异种族基因目录，并揭示了在疟原虫属中的外膜遗传控制的保守和专业特征。

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  • 来源
    《Cell Host & Microbe》 |2018年第3期|共22页
  • 作者

    Fraschka Sabine A.; Filarsky Michael; Hoo Regina; Niederwieser Igor; Yam Xue Yan; Brancucci Nicolas M. B.; Mohring Franziska; Mushunje Annals T.; Huang Ximei; Christensen Peter R.; Nosten Francois; Bozdech Zbynek; Russell Bruce; Moon Robert W.; Marti Matthias; Preiser Peter R.; Bartfai Richard; Voss Till S.;

  • 作者单位

    Radboud Univ Nijmegen Dept Mol Biol Fac Sci NL-6525 GA Nijmegen Netherlands;

    Swiss Trop &

    Publ Hlth Inst Dept Med Parasitol &

    Infect Biol CH-4051 Basel Switzerland;

    Nanyang Technol Univ Sch Biol Sci Singapore 637551 Singapore;

    Swiss Trop &

    Publ Hlth Inst Dept Med Parasitol &

    Infect Biol CH-4051 Basel Switzerland;

    Nanyang Technol Univ Sch Biol Sci Singapore 637551 Singapore;

    Univ Glasgow Inst Infect Immun &

    Inflammat Glasgow G12 8QQ Lanark Scotland;

    London Sch Hyg &

    Trop Med Dept Immunol &

    Infect London WC1E 7HT England;

    Nanyang Technol Univ Sch Biol Sci Singapore 637551 Singapore;

    Nanyang Technol Univ Sch Biol Sci Singapore 637551 Singapore;

    Mahidol Univ Fac Trop Med Shoklo Malaria Res Unit Mahidol Oxford Trop Med Res Unit Mae Sot 63110 Thailand;

    Mahidol Univ Fac Trop Med Shoklo Malaria Res Unit Mahidol Oxford Trop Med Res Unit Mae Sot 63110 Thailand;

    Nanyang Technol Univ Sch Biol Sci Singapore 637551 Singapore;

    Univ Otago Dept Microbiol &

    Immunol Dunedin 9054 New Zealand;

    London Sch Hyg &

    Trop Med Dept Immunol &

    Infect London WC1E 7HT England;

    Univ Glasgow Inst Infect Immun &

    Inflammat Glasgow G12 8QQ Lanark Scotland;

    Nanyang Technol Univ Sch Biol Sci Singapore 637551 Singapore;

    Radboud Univ Nijmegen Dept Mol Biol Fac Sci NL-6525 GA Nijmegen Netherlands;

    Swiss Trop &

    Publ Hlth Inst Dept Med Parasitol &

    Infect Biol CH-4051 Basel Switzerland;

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  • 正文语种 eng
  • 中图分类 普通生物学;
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