NADH Ties One-Carbon Metabolism to Cellular Respiration

Maynard Adam G.; Kanarek Naama

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NADH Ties One-Carbon Metabolism to Cellular Respiration

机译：NADH将单碳代谢与细胞呼吸联系起来

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In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation.

机译：在该问题的细胞代谢中，杨等人，2020年报告称，丝氨酸是源自单碳代谢的线粒体纳达的来源。当抑制细胞呼吸和未使用的累积NADH抑制TCA循环并减慢增殖时，丝氨酸成为NADH的主要来源。

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《Cell metabolism》 |2020年第4期|共3页
作者
Maynard Adam G.; Kanarek Naama;
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Harvard Med Sch Program Biol &

Biomed Sci Boston MA 02115 USA;

Boston Childrens Hosp Dept Pathol 300 Longwood Ave Boston MA 02115 USA;

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原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. NADH Ties One-Carbon Metabolism to Cellular Respiration [J] . Maynard Adam G., Kanarek Naama Cell metabolism . 2020,第4期

机译：NADH将单碳代谢与细胞呼吸联系起来
2. Methylmalonate impairs mitochondrial respiration supported by NADH-linked substrates: Involvement of mitochondrial glutamate metabolism [J] . MeloD.R., MirandolaS.R., Assun??oN.A., Journal of Neuroscience Research . 2012,第6期

机译：甲基丙酸酯损害NADH连接基材支持的线粒体呼吸：线粒体谷氨酸代谢的累积
3. Effect of NADH dehydrogenase-disruption and over-expression on respiration-related metabolism in Corynebacterium glutamicum KY9714 [J] . Nantapong N, Kugimiya Y, Toyama H, Applied Microbiology and Biotechnology . 2004,第2期

机译：NADH脱氢酶的破坏和过表达对谷氨酸棒杆菌KY9714呼吸相关代谢的影响
4. Effects of glucose and one-carbon metabolites on mitochondrial respiration in bovine embryonic cells [C] . EAAP International Symposium on Energy and Protein Metabolism . 2019

机译：葡萄糖和单碳代谢物对牛胚胎细胞线粒体呼吸的影响
5. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal: A mechanism of free radical mediated mitochondrial dysfunction. [D] . Humphries, Kenneth Michael. 2000

机译：4-羟基-2-壬烯醛抑制NADH连锁的线粒体呼吸：自由基介导的线粒体功能障碍的机制。
6. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice [O] . Noga Ron-Harel, Giulia Notarangelo, Jonathan M. Ghergurovich, 2018

机译：呼吸缺陷和一碳代谢导致衰老小鼠幼稚T细胞活化受损
7. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice [O] . Noga Ron-Harel, Giulia Notarangelo, Jonathan M. Ghergurovich, 2018

机译：缺陷的呼吸和单碳代谢有助于较老年小鼠的幼稚T细胞活化效应受损

NADH Ties One-Carbon Metabolism to Cellular Respiration

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