Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson; Ofer Mandelboim

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Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

机译：甜杀手：NK细胞需要糖酵解杀死肿瘤

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Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue ofCell Metabolism, demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.

机译：天然杀手（NK）细胞是细胞毒性先天淋巴细胞，其在免疫癌症中发挥着重要作用。在该问题中，表明肿瘤的进展降低了NK细胞糖醛能力，这导致细胞毒性降低和整体功能障碍NK表型。

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《Cell metabolism》 |2018年第2期|共2页
作者
Batya Isaacson; Ofer Mandelboim;
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作者单位

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research;

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Sweet Killers: NK Cells Need Glycolysis to Kill Tumors [J] . Batya Isaacson, Ofer Mandelboim Cell metabolism . 2018,第2期

机译：甜杀手：NK细胞需要糖酵解杀死肿瘤
2. Hepatic natural killer cells exclusively kill splenic/blood natural killer-resistant tumor cells by the perforin/granzyme pathway. [J] . Wisse E Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2002,第4期

机译：肝天然杀伤细胞通过穿孔素/粒酶途径专门杀死脾/血液抗自然杀伤剂的肿瘤细胞。
3. Making potent "killer" of tumor cells useful: Immunotherapy with allogeneic NK cells after stem cell transplantation [Immuntherapien mit allogenen NK-Zellen nach Stammzelltransplantation: Potente "killer" von Tumorzellen nutzbar machen] [J] . Kl??S., K?hlU. Pharmazie in Unserer Zeit . 2012,第3期

机译：使有效的肿瘤细胞“杀手”有用：干细胞移植后同种异体NK细胞的免疫治疗
4. Imaging Lung Clearance of Radio labeled Tumor Cells to Study Mice with Normal, Activated or Depleted Natural Killer (NK) Cells [C] . P.V. Kulkarni, M. Bennett, A. Constantinescu, Application of Accelerators in Research and Industry . 2003

机译：对放射性标记的肿瘤细胞的肺间隙进行成像，以研究具有正常，活化或耗尽的自然杀伤（NK）细胞的小鼠
5. IMMUNE RESPONSE TO ULTRAVIOLET-INDUCED TUMORS: TRANSPLANTATION IMMUNITY AND LYMPHOCYTE POPULATIONS EXHIBITING ANTI-TUMOR ACTIVITY (CYTOLYTIC T, CLONES, NATURAL KILLER CELLS). [D] . STREETER, PHILIP REEL. 1985

机译：对紫外线诱导的肿瘤的免疫反应：移植免疫和具有抗肿瘤活性的淋巴细胞（细胞分裂性T，克隆，天然杀伤细胞）。
6. Interactions between human natural killer (NK) lymphocytes and yeast cells: human NK cells do not kill Candida albicans although C. albicans blocks NK lysis of K562 cells. [O] . S J Zunino, D Hudig 1988

机译：人类自然杀伤（NK）淋巴细胞与酵母细胞之间的相互作用：尽管白色念珠菌能阻止K562细胞的NK裂解但人类NK细胞不会杀死白色念珠菌。
7. Sweet Killers: NK Cells Need Glycolysis to Kill Tumors [O] . Batya Isaacson, Ofer Mandelboim 2018

机译：甜杀手：NK细胞需要糖酵解杀死肿瘤

Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

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