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首页> 外文期刊>Cell metabolism >GDF15 Induces Anorexia through Nausea and Emesis
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GDF15 Induces Anorexia through Nausea and Emesis

机译：GDF15通过恶心和呕吐诱导厌食症

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Growth differentiation factor 15 (GDF15) is a cytokine that reduces food intake through activation of hindbrain GFRAL-RET receptors and has become a keen target of interest for antiobesity therapies. Elevated endogenous GDF15 is associated with energy balance disturbances, cancer progression, chemotherapy-induced anorexia, and morning sickness. We hypothesized that GDF15 causes emesis and that its anorectic effects are related to this function. Here, we examined feeding and emesis and/or emetic-like behaviors in three different mammalian laboratory species to help elucidate the role of GDF15 in these behaviors. Data show that GDF15 causes emesis in Suncus murinus (musk shrews) and induces behaviors indicative of nausea/malaise (e.g., anorexia and pica) in non-emetic species, including mice and lean or obese rats. We also present data in mice suggesting that GDF15 contributes to chemotherapy-induced malaise. Together, these results indicate that GDF15 triggers anorexia through the induction of nausea and/or by engaging emetic neurocircuitry.
机译：生长分化因子15（GDF15）是一种细胞因子，其通过激活后褐色 - RET受体来减少食物摄取，并且已成为抗菌疗法感兴趣的敏锐目标。升高的内源性GDF15与能量平衡紊乱，癌症进展，化疗诱导的厌食和孕吐有关。我们假设GDF15导致呕吐，并且其匿名效应与该功能有关。在这里，我们检查了三种不同哺乳动物实验室物种中的喂养和呕吐和/或逼测的行为，以帮助阐明GDF15在这些行为中的作用。数据显示，GDF15在日子穆里斯（麝香Shrews）中产生呕吐，并诱导非逼测物种中恶心/萎靡不振（例如，厌食症和PICA）的行为，包括小鼠和瘦或肥胖的大鼠。我们还提出小鼠的数据，表明GDF15有助于化疗诱导的不适。这些结果表明，GDF15通过诱导恶心和/或通过接合催眠神经激核来触发厌食。

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