Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease

Tsai Sue; Winer Shawn; Winer Daniel A.

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Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease

机译：Gut T细胞盛宴GLP-1调节心脏素质疾病

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Glucagon-like peptide-1 (GLP-1) is an enteroendocrine hormone that controls insulin secretion, intestinal function, and food intake. Recently in Nature, He et al. (2019) reported that gut intraepithelial T cells regulate GLP-1 bioavailability by capturing it on GLP-1 receptors and impacting L-cell numbers. This study delineates a novel endocrine-immune axis through which intestinal immune cells regulate whole-body metabolism.

机译：胰高血糖素类肽-1（GLP-1）是一种控制胰岛素分泌，肠功能和食物摄入的肠内分泌激素。最近本质上，赫尔·埃拉。（2019）报道，通过在GLP-1受体上捕获并撞击L细胞数来调节GUT上皮内T细胞调节GLP-1生物利用度。本研究描绘了一种新的内分泌免疫轴，通过该肠免疫细胞调节全身代谢。

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《Cell metabolism》 |2019年第4期|共3页
作者
Tsai Sue; Winer Shawn; Winer Daniel A.;
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作者单位

Univ Hlth Network TGHRI Diabet Res Grp Div Cellular &

Mol Biol Toronto ON M5G 1L7 Canada;

Univ Toronto Dept Lab Med &

Pathobiol Toronto ON M5S 1A8 Canada;

Univ Hlth Network TGHRI Diabet Res Grp Div Cellular &

Mol Biol Toronto ON M5G 1L7 Canada;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease [J] . Tsai Sue, Winer Shawn, Winer Daniel A. Cell metabolism . 2019,第4期

机译：Gut T细胞盛宴GLP-1调节心脏素质疾病
2. The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans. [J] . De Silva A, Salem V, Long CJ, Cell metabolism . 2011,第5期

机译：肠道激素PYY 3-36和GLP-1 7-36酰胺会减少食物摄入量并调节人食欲中枢的大脑活动。
3. The Use of Probiotic Therapy to Modulate the Gut Microbiota and Dendritic Cell Responses in Inflammatory Bowel Diseases [J] . Pablo Alagón Fernández del Campo, Alejandro De Orta Pando, Juan Ignacio Straface, Medical Sciences . 2019,第2期

机译：益生菌疗法在炎症性肠病中调节肠道菌群和树突状细胞反应的应用
4. Site-Directed Polymer-Drug Complexes for Modulating Gut Innate Immune System to Prevent/Treat Inflammatory Bowel Diseases(IBD) [C] . KesharwaniS., AhmadR., RajputM. Bioengineering and Translational Medicine Conference . 2018

机译：用于调节肠道先天免疫系统的部位定向聚合物 - 药物复合物，以预防/治疗炎症性肠病（IBD）
5. Impact of Activated and Resting Mesenchymal Stem Cells on Immune Responses and Gut Microbiome and Immune Responses to Gut Bacteria in Dogs With Inflammatory Bowel Disease [D] . Soontararak, Sirikul. 2019

机译：活化和休息间充质干细胞对炎症性肠病犬肠道细菌的免疫应答和肠道微生物组和免疫应答的影响
6. Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota [O] . Ming Lyu, Yue-fei Wang, Guan-wei Fan, -1

机译：通过调节肠道菌群来平衡草药和功能性食品以预防和治疗心脏代谢疾病
7. Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota [O] . Ming Lyu, Yue-fei Wang, Guan-wei Fan, 2017

机译：通过调节肠道微生物群来平衡草药和功能性食品预防和治疗心脏代谢疾病

Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease

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