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Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories

机译:日常禁食改善了雄性小鼠的健康和生存,无论饮食成分和卡路里

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摘要

The importance of dietary composition and feeding patterns in aging remains largely unexplored, but was implicated recently in two prominent nonhuman primate studies. Here, we directly compare in mice the two diets used in the primate studies focusing on three paradigms: ad libitum (AL), 30% calorie restriction (CR), and single-meal feeding (MF), which accounts for differences in energy density and caloric intake consumed by the AL mice. MF and CR regimes enhanced longevity regardless of diet composition, which alone had no significant impact within feeding regimens. Like CR animals, MF mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared with AL. These health and survival benefits conferred by periods of extended daily fasting, independent of dietary composition, have major implications for human health and clinical applicability.
机译:饮食成分和饲养模式在衰老中的重要性仍然很大程度上是未开发的,但最近涉及两个突出的非人类灵长类动物研究。 在这里,我们直接在小鼠中比较了在灵长类动物研究中使用的两种饮食,重点关注三个范式:AD Libitum(Al),30%卡路里限制(Cr)和单粉饲料(MF),其占能量密度的差异 和Al小鼠消耗的热量摄入量。 无论饮食组合物,MF和CR制度都增强了寿命,单独在喂食方案内没有显着影响。 像Cr动物一样,MF小鼠快速吃,施加的日常速度延长,与AL相比,发病率和死亡率的显着改善。 这些健康和生存效益赋予延长日常禁食,独立于膳食组成,对人类健康和临床适用性具有重大影响。

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