Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

Benador Ilan Y.; Veliova Michaels; Liesa Marc; Shirihai Orian S.

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Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

机译：线粒体与脂液滴结合：其中线粒体动力学调节脂质储存和利用

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The isolation and biochemical characterization of lipid droplet (LD)-associated mitochondria revealed the capacity of the cell to produce and maintain distinct mitochondrial populations carrying disparate proteome and dissimilar capacities to oxidize fatty acids and pyruvate. With mitochondrial motility being a central parameter determining mitochondrial fusion, adherence to LDs provides a mechanism by which peridroplet mitochondria (PDM) remain segregated from cytoplasmic mitochondria (CM). The existence of metabolically distinct subpopulations provides an explanation for the capacity of mitochondria within the individual Cell to be involved simultaneously in fatty acid oxidation and LD formation. The mechanisms that deploy mitochondria to the LD and the dysfunctions that result from unbalanced proportions of PDM and CM remain to be explored. Understanding the roles and regulation of mitochondrial tethering to LDs offers new points of intervention in metabolic diseases.

机译：脂质液滴（LD）的分离和生化表征 - 分类的线粒体揭示了细胞产生和维持具有不同蛋白质组和异种能力的不同线粒体群的能力，以氧化脂肪酸和丙酮酸。通过线粒体运动是一种确定线粒体融合的中央参数，对LDS的粘附提供了一种机制，通过该机制由细胞质线粒体（cm）保持偏见。代谢不同的亚步骤的存在提供了在脂肪酸氧化和LD形成中同时涉及单个细胞内的线粒体的能力的解释。将线粒体部署到LD的机制以及由不平衡比例的PDM和CM的不平衡比例结果仍有待探索。理解线粒体系律的作用和调节对LDS提供新的代谢疾病的介入点。

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《Cell metabolism》 |2019年第4期|共9页
作者
Benador Ilan Y.; Veliova Michaels; Liesa Marc; Shirihai Orian S.;
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Univ Calif Los Angeles David Geffen Sch Med Div Endocrinol Dept Med Los Angeles CA 90095 USA;

Univ Calif Los Angeles David Geffen Sch Med Div Endocrinol Dept Med Los Angeles CA 90095 USA;

Univ Calif Los Angeles David Geffen Sch Med Div Endocrinol Dept Med Los Angeles CA 90095 USA;

Univ Calif Los Angeles David Geffen Sch Med Div Endocrinol Dept Med Los Angeles CA 90095 USA;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization [J] . Benador Ilan Y., Veliova Michaels, Liesa Marc, Cell metabolism . 2019,第4期

机译：线粒体与脂液滴结合：其中线粒体动力学调节脂质储存和利用
2. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion [J] . Benador Ilan Y., Veliova Michaela, Mahdaviani Kiana, Cell metabolism . 2018,第4期

机译：与脂液滴相结合的线粒体具有独特的生物植物，组成和动力学，可支持脂液滴膨胀
3. Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization [J] . KimmelA.R., SztalrydC. Current opinion in lipidology . 2014,第2期

机译：Perilipin 5，一种适合线粒体能量利用的脂滴蛋白
4. Doxorubicin-Induced Mitochondrial Toxicity and Metabolomic Lipid Profile [C] . Ying Zhou, Meredith Crosby, Harriet Kamendi ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：多柔比蛋白诱导的线粒体毒性和代谢物脂质分析
5. PspA Regulates Lipid Droplet Homeostasis and Bacterial Persistence in Mycobacterium, and is a Model for Studying Protein-Lipid Droplet Interaction in Prokaryotes [D] . Armstrong, Richard M. Lewis 2018

机译：PspA调节分枝杆菌中的脂质液滴稳态和细菌持久性，是研究原核生物中蛋白质-脂质液滴相互作用的模型。
6. Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics Composition and Dynamics That Support Lipid Droplet Expansion [O] . Ilan Y. Benador, Michaela Veliova, Kiana Mahdaviani, -1

机译：绑定到脂质滴的线粒体具有独特的生物能组成和动力学可支持脂质滴的扩展
7. Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization [O] . Ilan Y. Benador, Michaela Veliova, Marc Liesa, 2019

机译：线粒体与脂液滴结合：其中线粒体动力学调节脂质储存和利用

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

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