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首页> 外文期刊>Cell metabolism >Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure
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Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure

机译：通过增加的能量消耗激活焦炭发生电路的激活煽动抗饮食肥胖症

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摘要

Anxiety disorders are associated with body weight changes in humans. However, the mechanisms underlying anxiety-induced weight changes remain poorly understood. Using Emx(cre/+) mice, we deleted the gene for brain-derived neurotrophic factor (BDNF) in the cortex, hippocampus, and some amygdalar subregions. The resulting mutant mice displayed impaired GABAergic transmission and elevated anxiety. They were leaner when fed either a chow diet or a high-fat diet, owing to higher sympathetic activity, basal metabolic rate, brown adipocyte thermogenesis, and beige adipocyte formation, compared to control mice. BDNF re-expression in the amygdala rescued the anxiety and metabolic phenotypes in mutant mice. Conversely, anxiety induced by amygdala-specific Bdnf deletion or administration of an inverse GABA(A) receptor agonist increased energy expenditure. These results reveal that increased activities in anxiogenic circuits can reduce body weight by promoting adaptive thermogenesis and basal metabolism via the sympathetic nervous system and suggest that amygdalar GABAergic neurons are a link between anxiety and metabolic dysfunction.
机译：焦虑症与人类体重变化有关。然而，焦虑诱导的体重变化的潜在机制仍然明白很差。使用EMX（CRE / +）小鼠，我们将基因删除了皮质，海马和一些杏仁次区域中的脑衍生的神经营养因子（BDNF）。所得突变小鼠显示出加布的传播损害，焦虑率升高。与对照小鼠相比，它们喂食味道饮食或高脂饮食时，喂食味道饮食或高脂饮食时，基础代谢率，棕色脂肪细胞热量和米色adipocyte形成。在Amygdala中的BDNF重新表达拯救了突变小鼠中的焦虑和代谢表型。相反，由Amygdala特异性BDNF缺失或施用逆GABA（a）受体激动剂的焦虑增加了能量消耗。这些结果表明，通过同情神经系统促进适应性的热生成和基础代谢可以降低体重，并表明Amygdalar Gabaeric神经元是焦虑和代谢功能障碍之间的联系。

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  • 来源
    《Cell metabolism》 |2019年第4期|共19页
  • 作者

    Xie Xiangyang; Yang Haili; An Juan Ji; Houtz Jessica; Tan Ji-Wei; Xu Haifei; Liao Guey-Ying; Xu Zhi-Xiang; Xu Baoji;

  • 作者单位

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

    Scripps Res Inst Florida Dept Neurosci Jupiter FL 33458 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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