...
首页> 外文期刊>Cell metabolism >Causes, Characteristics, and Consequences of Metabolically Unhealthy Normal Weight in Humans
【24h】

Causes, Characteristics, and Consequences of Metabolically Unhealthy Normal Weight in Humans

机译:人类代谢不健康正常重量的原因,特征和后果

获取原文
获取原文并翻译 | 示例
           

摘要

A BMI in the normal range associates with a decreased risk of cardiometabolic disease and all-cause mortality. However, not all subjects in this BMI range have this low risk. Compared to people who are of normal weight and metabolically healthy, subjects who are of normal weight but metabolically unhealthy (similar to 20% of the normal weight adult population) have a greater than 3-fold higher risk of all-cause mortality and/or cardiovascular events. Here we address to what extent major risk phenotypes determine metabolic health in lean compared to overweight and obese people and provide support for the existence of a lipodystrophy-like phenotype in the general population. Furthermore, we highlight the molecular mechanisms that induce this phenotype. Finally, we propose strategies as to how this knowledge could be implemented in the prevention and treatment of cardiometabolic diseases in different stages of adiposity in routine clinical practice.
机译:在正常范围内的BMI伙伴患者的心肌植物疾病风险降低和全导致死亡率。 然而,并非所有BMI范围内的受试者都具有这种低风险。 与具有正常重量和代谢性健康的人相比,具有正常体重但代谢不健康的受试者(类似于正常体重的20%)的全部导致死亡率和/或患者的风险高于3倍。 心血管事件。 在这里,与超重和肥胖人员相比,我们在多大程度上提出了主要风险表型的主要风险表型,并提供了对一般人群中的脂肪育种表现形式的存在的支持。 此外,我们突出了诱导这种表型的分子机制。 最后,我们提出了如何在常规临床实践中预防和治疗不同阶段的心细管疾病的预防和治疗方法中实施策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号