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首页> 外文期刊>Cell metabolism >Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice
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Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice

机译：棕色脂肪细胞的脂解不是小鼠冷诱导的热生成必需

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Summary Lipid droplet (LD) lipolysis in brown adipose tissue (BAT) is generally considered to be required for cold-induced nonshivering thermogenesis. Here, we show that mice lacking BAT Comparative Gene Identification-58 (CGI-58), a lipolytic activator essential for the stimulated LD lipolysis, have normal thermogenic capacity and are not cold sensitive. Relative to littermate controls, these animals had higher body?temperatures when they were provided food during cold exposure. The increase in body temperature in the fed, cold-exposed knockout mice was associated with increased energy expenditure and with increased sympathetic innervation and browning of white adipose tissue (WAT). Mice lacking CGI-58 in both BAT and WAT were cold sensitive, but only in the fasted state. Thus, LD lipolysis in BAT is not essential for cold-induced nonshivering thermogenesis in?vivo . Rather, CGI-58-dependent LD lipolysis in BAT regulates WAT thermogenesis, and our data uncover an essential role of WAT lipolysis in fueling thermogenesis during fasting. Graphical Abstract Display Omitted Highlights ? The stimulated lipolysis in BAT is not essential for cold-induced thermogenesis ? Mice defective in adipose lipolysis are not cold sensitive when food is present ? Inhibiting stimulated BAT lipolysis by CGI-58 deletion induces WAT browning ? WAT lipolysis is essential to defend body temperature during fasting Lipolysis in brown fat is generally considered to be required for cold-induced thermogenesis. Shin et?al. show that mice defective in brown fat lipolysis are not cold sensitive. These animals compensate for the defect by increasing white fat browning and combustion of fuels derived from diet or white fat lipolysis.
机译：发明内容脂质液滴（LD）棕色脂肪组织（BAT）中的脂解通常被认为是冷诱导的不敏感的热生成所必需的。在这里，我们表明缺乏BAT比较基因鉴定-58（CGI-58）的小鼠，脂肪激活剂是刺激的LD脂肪解的必需品，具有正常的热容量并且不冷敏感。相对于凋落物控制，这些动物的身体更高？在冷暴露过程中提供食物的温度。喂养的冷暴露敲除小鼠体温的增加与增加的能量消耗增加以及白色脂肪组织（WAT）的相同声链和褐变。缺乏CGI-58的小鼠在蝙蝠和WAT中都是冷敏感的，但仅在禁食状态下。因此，蝙蝠中的LD脂解不是对βvivo的冷诱导的不敏感的热生成必需的。相反，蝙蝠中的CGI-58依赖性LD脂解调节Wat热生成，我们的数据在禁食期间揭示Wat脂解的必要作用。图形抽象显示省略了亮点？蝙蝠中受刺激的脂解不是冷致热生成的必需？当出现食物时，在脂肪脂解中缺陷的小鼠对脂肪敏感？通过CGI-58缺失抑制刺激的蝙蝠脂解诱导Wat褐变？ Wat脂解对于防止体温是必不可少的，在棕色脂肪中禁食脂肪解析，通常被认为是冷诱导的热生成所需的。 shin等。表明棕色脂肪脂肪分解缺陷的小鼠不是冷敏感的。这些动物通过增加白脂肪褐变和燃料燃料燃烧的饮食或白脂肪脂肪解的燃烧来补偿缺陷。

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