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首页> 外文期刊>Cell metabolism >Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
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Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise

机译：细胞外囊泡在运动期间提供用于组织串扰的手段

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Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged in extracellular vesicles (EVs), we employed quantitative proteomic techniques to characterize the exercise-induced secretion of EV-contained proteins. Following a 1-hr bout of cycling exercise in healthy humans, we observed an increase in the circulation of over 300 proteins, with a notable enrichment of several classes of proteins that compose exosomes and small vesicles. Pulse-chase and intravital imaging experiments suggested EVs liberated by exercise have a propensity to localize in the liver and can transfer their protein cargo. Moreover, by employing arteriovenous balance studies across the contracting human limb, we identified several novel candidate myokines, released into circulation independently of classical secretion. These data identify a new paradigm by which tissue crosstalk during exercise can exert systemic biological effects.
机译：锻炼刺激分子释放到循环中，支持组织间信号蛋白是锻炼的适应性重要介质的概念。认识到许多循环蛋白质在细胞外囊泡中包装（EVS），我们采用定量蛋白质组学技术来表征EV含有蛋白质的运动诱导的分泌。在健康的人类中获得1小时循环运动之后，我们观察到300多种蛋白质的循环增加，其中几种蛋白质具有显着的富集，这些蛋白质构成外泌体和小囊泡。脉冲追逐和流体腔内成像实验表明，通过运动释放的EVS具有倾向于肝脏的倾向，可以转移其蛋白质货物。此外，通过在合同人肢体上采用动静脉余额研究，我们确定了几种新型候选肌电站，独立于古典分泌释放到循环中。这些数据鉴定了一种新的范例，锻炼期间的组织串扰可以施加全身的生物效应。

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