Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients

Reber Josefine; Willershaeuser Monja; Karlas Angelos; Paul-Yuan Korbinian; Diot Gael; Franz Daniela; Fromme Tobias; Ovsepian Saak V.; Beziere Nicolas; Dubikovskaya Elena; Karampinos Dimitrios C.; Holzapfel Christina; Hauner Hans; Klingenspor Martin; Ntziachristos Vasilis

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Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients

机译：基于血红蛋白梯度光声成像的棕色脂肪代谢的非侵入性测量

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Metabolism is a fundamental process of life. However, non-invasive measurement of local tissue metabolism is limited today by a deficiency in adequate tools for in vivo observations. We designed a multi-modular platform that explored the relation between local tissue oxygen consumption, determined by label-free optoacoustic measurements of hemoglobin, and concurrent indirect calorimetry obtained during metabolic activation of brown adipose tissue (BAT). By studying mice and humans, we show how video-rate handheld multi-spectral optoacoustic tomography (MSOT) in the 700-970 nm spectral range enables non-invasive imaging of BAT activation, consistent with positron emission tomography findings. Moreover, we observe BAT composition differences between healthy and diabetic tissues. The study consolidates hemoglobin as a principal label-free biomarker for longitudinal non-invasive imaging of BAT morphology and bioenergetics in situ. We also resolve water and fat components in volunteers, and contrast MSOT readouts with magnetic resonance imaging data.

机译：新陈代谢是生命的基本过程。然而，今天通过适用于体内观察的适当工具的缺陷来限制局部组织代谢的非侵入性测量。我们设计了一种多模块化平台，探讨了局部组织氧气消耗之间的关系，由血红蛋白的无标签光声测量确定，以及在棕色脂肪组织（BAT）的代谢活化期间获得的并发间接热量。通过研究小鼠和人类，我们展示了700-970nm光谱范围内的视频速率掌上电持多光声断层扫描（MSOT）如何实现蝙蝠激活的非侵入性成像，与正电子发射断层摄影结果一致。此外，我们观察健康和糖尿病组织之间的蝙蝠组成差异。该研究将血红蛋白巩固为一个主要的无侵入性生物标志物，用于蝙蝠形态和生物终端的纵向非侵入性成像原位。我们还解决了志愿者的水和脂肪组件，并用磁共振成像数据对比MSOT读数。

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《Cell metabolism》 |2018年第3期|共17页
作者
Reber Josefine; Willershaeuser Monja; Karlas Angelos; Paul-Yuan Korbinian; Diot Gael; Franz Daniela; Fromme Tobias; Ovsepian Saak V.; Beziere Nicolas; Dubikovskaya Elena; Karampinos Dimitrios C.; Holzapfel Christina; Hauner Hans; Klingenspor Martin; Ntziachristos Vasilis;
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作者单位

Helmholtz Zentrum Munchen Inst Biol &

Med Imaging Neuherberg Germany;

Tech Univ Munich TUM Sch Life Sci Chair Mol Nutr Med Freising Weihenstephan Germany;

Helmholtz Zentrum Munchen Inst Biol &

Med Imaging Neuherberg Germany;

Helmholtz Zentrum Munchen Inst Biol &

Med Imaging Neuherberg Germany;

Helmholtz Zentrum Munchen Inst Biol &

Med Imaging Neuherberg Germany;

Tech Univ Munich Dept Diagnost &

Intervent Radiol Munich Germany;

Tech Univ Munich TUM Sch Life Sci Chair Mol Nutr Med Freising Weihenstephan Germany;

Helmholtz Zentrum Munchen Inst Biol &

Med Imaging Neuherberg Germany;

Helmholtz Zentrum Munchen Inst Biol &

Med Imaging Neuherberg Germany;

Ecole Polytech Fed Lausanne Dept Chem Lausanne Switzerland;

Tech Univ Munich Dept Diagnost &

Intervent Radiol Munich Germany;

Tech Univ Munich Inst Nutr Med Sch Med Munich Germany;

Tech Univ Munich EKFZ Else Kroner Fresenius Ctr Nutr Med Freising Weihenstephan Germany;

Tech Univ Munich TUM Sch Life Sci Chair Mol Nutr Med Freising Weihenstephan Germany;

Helmholtz Zentrum Munchen Inst Biol &

Med Imaging Neuherberg Germany;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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专利

1. Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients [J] . Reber Josefine, Willershaeuser Monja, Karlas Angelos, Cell metabolism . 2018,第3期

机译：基于血红蛋白梯度光声成像的棕色脂肪代谢的非侵入性测量
2. Optical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: clinical application of total hemoglobin measurements in the breast [J] . Shigeto Ueda, Noriko Nakamiya, Kazuo Matsuura, BMC Cancer . 2013,第1期

机译：早期乳腺癌中与血管增生和葡萄糖代谢相关的肿瘤血管的光学成像：乳腺癌中总血红蛋白测量的临床应用
3. Non-invasive quantification of hepatic fat content in healthy dogs by using proton magnetic resonance spectroscopy and dual gradient echo magnetic resonance imaging [J] . Del Chicca Francesca, Schwarz Andrea, Meier Dieter, Journal of Veterinary Science . 2018,第4期

机译：使用质子磁共振光谱和双梯度回波磁共振成像，非侵入性定量健康犬肝脂肪含量
4. Simultaneous measurements of total hemoglobin concentration and blood oxygenation with laser diode-based optoacoustic system [C] . Irene Y. Petrov, Donald S. Prough, Yuriy Petrov, Conference on photons plus ultrasound: imaging and sensing . 2017

机译：基于激光二极管的光声系统同时测量总血红蛋白浓度和血液氧合
5. Non-Invasive Measurements of Muscle Microstructure Using Diffusion Tensor Imaging in Active-Duty Marines. [D] . Berry, David Barnes. 2017

机译：在现役海军陆战队中使用扩散张量成像对肌肉微结构进行无创测量。
6. Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients—a pilot clinical study [O] . Angelos Karlas, Max Masthoff, Michael Kallmayer, 2021

机译：基于肌肉血红蛋白梯度的外周动脉疾病多光谱光声断层扫描 - 试验临床研究
7. Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients [O] . Josefine Reber, Monja Willershäuser, Angelos Karlas, 2018

机译：基于血红蛋白梯度光声成像的棕色脂肪代谢的非侵入性测量

Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients

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