AMPK Regulates the Epigenome through Phosphorylation of TET2

Fiedler Eleanor C.; Shaw Reuben J.

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AMPK Regulates the Epigenome through Phosphorylation of TET2

机译：AMPK通过TET2的磷酸化来调节外延蛋白酶

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Emerging evidence suggests that changes to cellular metabolism can regulate epigenetic modifications to alter gene expression. Recently in Nature, Wu et al. show that the metabolic regulator AMPK can phosphorylate and thus stabilize the epigenetic modifying enzyme TET2, defining a novel signaling link between metabolism and the epigenome.

机译：新兴的证据表明对细胞新陈代谢的变化可以调节脑膜遗传学修饰来改变基因表达。最近在大自然中，Wu等人。表明代谢调节剂AMPK可以磷酸化，从而稳定表观遗传修饰酶TET2，定义新陈代谢和外观蛋白酶之间的新型信号环节。

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《Cell metabolism》 |2018年第4期|共4页
作者
Fiedler Eleanor C.; Shaw Reuben J.;
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Salk Inst Biol Studies Lab Mol &

Cell Biol 10010 N Torrey Pines Rd La Jolla CA 92037 USA;

Salk Inst Biol Studies Lab Mol &

Cell Biol 10010 N Torrey Pines Rd La Jolla CA 92037 USA;

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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. AMPK Regulates the Epigenome through Phosphorylation of TET2 [J] . Fiedler Eleanor C., Shaw Reuben J. Cell metabolism . 2018,第4期

机译：AMPK通过TET2的磷酸化来调节外延蛋白酶
2. Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation [J] . Ting Zhang, Xiaowen Guan, Un Lam Choi, Epigenetics & Chromatin . 2019,第1期

机译：AMPK使TET2磷酸化在成肌分化中必不可少
3. Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis [J] . Jeong Jong Jin, Gu Xiaorong, Nie Ji, Cancer discovery. . 2019,第6期

机译：Cytokine-Crougupt磷酸化和TET2在造血中的TET2
4. The positive effect of metformin on reproduction is through its action on AMPK in GT1-7 cells to regulate KISS1R, and GNRH1 expression [C] . Jingyun Fu, Xuan Qu, Jun Zhong, International Conference on Biological Information and Biomedical Engineering . 2019

机译：二甲双胍对繁殖的积极作用是通过其对GT1-7细胞中的AMPK的作用来调节Kiss1R，以及GNRH1表达
5. Phosphorylation of TET2 by AMPK Is Indispensable in Myogenic Differentiation [D] . Zhang, Ting. 2019

机译：AMPK的TET2的磷酸化在肌源性分化中是必不可少的
6. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer [O] . Di Wu, Di Hu, Hao Chen, -1

机译：AMPK对葡萄糖调节的TET2磷酸化揭示了将糖尿病与癌症联系起来的途径
7. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer [O] . Di Wu, Di Hu, Hao Chen, 2018

机译：AMPK的TET2的葡萄糖调节磷酸化揭示了将糖尿病连接到癌症的途径

AMPK Regulates the Epigenome through Phosphorylation of TET2

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