...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >New Advances in Adaptive Thermogenesis: UCP1 and Beyond
【24h】

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

机译：自适应热生成的新进展：UCP1及以后

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like obesity and type 2 diabetes. Thermogenic adipocytes drive heat production through close coordination of substrate supply with the mitochondrial oxidative machinery and effectors that control the rate of substrate oxidation. Together, this apparatus affords these adipocytes with tremendous capacity to drive thermogenesis. The best characterized thermogenic effector is uncoupling protein 1 (UCP1). Importantly, additional mechanisms for activating thermogenesis beyond UCP1 have been identified and characterized to varying extents. Acute regulation of these thermogenic pathways has been an active area of study, and numerous regulatory factors have been uncovered in recent years. Here we will review the evidence for regulators of heat production in thermogenic adipocytes in the context of the thermodynamic and kinetic principles that govern their therapeutic utility.
机译：棕色和米色脂肪细胞可以将储存的能量分解成产生热量，并且可以将这种明显的热生成能力作为肥胖和2型糖尿病等代谢疾病的治疗。热生成脂肪细胞通过用线粒体氧化机械和控制衬底氧化速率的线粒体氧化机械和效应器来驱动热量。该仪器在一起提供这些脂肪细胞，具有巨大的驱动热固性能力。最佳表征的热效应器是解偶联蛋白1（UCP1）。重要的是，已经鉴定了在UCP1之外激活热生成的额外机制并表征到不同的范围。这些热原途径的急性调节一直是一种活跃的研究领域，近年来已经发现了许多监管因素。在这里，我们将在治疗其治疗效用的热力学和动力学原理的背景下审查热生殖脂肪细胞中热量产量监管机构的证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号