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首页> 外文期刊>Cell metabolism >Neuromedin U Does Not Act as a Decretin in Rats
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Neuromedin U Does Not Act as a Decretin in Rats

机译：神经细胞素不作为大鼠的副霉素

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摘要

Studies on isolated pancreatic islets suggest that neuromedin U (NMU), a brain and gastrointestinal peptide, acts as a decretin hormone, inhibiting glucose-stimulated insulin secretion. We investigated whether this effect could be reproduced in vivo and in isolated perfused rat pancreas. Unlike the incretin hormone, glucagon-like peptide 1 (GLP-1), intravenous NMU administration had no effects on blood glucose and plasma insulin and glucagon in vivo. Moreover, NMU neither changed insulin, glucagon, or somatostatin secretion from isolated perfused rat pancreas, nor affected GLP-1-stimulated insulin and somatostatin secretion. For NMU to act as a decretin hormone, its secretion should increase following glucose ingestion; however, glucose did not affect NMU secretion from isolated perfused rat small intestine, which contained extractable NMU. Furthermore, the two NMU receptors were not detected in endocrine rat or human pancreas. We conclude that NMU does not act as a decretin hormone in rats.
机译：孤立的胰岛胰岛的研究表明，神经细胞素U（NMU），脑和胃肠肽，作为抑制葡萄糖刺激的胰岛素分泌的抑制葡萄糖激素。我们研究了这种效果是否可以在体内和分离的灌注大鼠胰腺中复制。与Incetin激素不同，胰高血糖素样肽1（GLP-1），静脉内NMU给药对血糖和血浆胰岛素和体内胰高血糖素没有影响。此外，NMU既不发生胰岛素，胰高血糖素或生长抑制素分泌来自分离的灌注大鼠胰腺，也没有受影响GLP-1刺激的胰岛素和生长抑素分泌。对于NMU充当糖尿病激素，其分泌应在葡萄糖摄入后增加;然而，葡萄糖不会影响来自分离的灌注大鼠小肠的NMU分泌，其含有可提取的NMU。此外，在内分泌大鼠或人胰腺中未检测到两种NMU受体。我们得出结论，NMU不作为大鼠的副霉素。

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