...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis
【24h】

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

机译：人棕色脂肪的餐后氧化代谢表明热生成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in?postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We?identified several genes participating in lipid metabolism to be expressed at higher levels in BAT?compared with white fat in postprandial state, and to be positively correlated with BATUCP1expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.
机译：人类研究表明，膳食升高了棕色脂肪组织（蝙蝠）的葡萄糖摄取。然而，在蝙蝠中，蝙蝠中非酯化脂肪酸（Nefas）的热活性和代谢仍然尚不清楚。使用间接量热法与正电子发射断层扫描和计算机断层扫描（PET / CT）相结合，我们表明，在摄入混合的碳水化合物的膳食后，全身和蝙蝠热生成（氧气消耗）增加，与冷应激相同。餐后NEFA吸收蝙蝠是最小的，可能是由于血浆胰岛素抑制脂肪分解的升高。然而，餐后NEFA摄取的变化与BAT热生成相关。我们鉴定了参与脂质代谢的几个基因，以蝙蝠的更高水平表达？与餐后状态下的白色脂肪相比，与Batucp1表达呈正相关。这些发现表明，由于胰岛素刺激，由蝙蝠优选的蝙蝠优选的是葡萄糖或LPL释放的Nefas。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号