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首页> 外文期刊>Cell metabolism >FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake
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FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

机译：FGF21向腹侧下丘脑中的谷氨酸神经元发出信号，以抑制碳水化合物摄入量

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摘要

Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in response to macronutrient imbalance and signals to the brain to suppress sugar intake and sweet-taste preference. However, the central targets mediating these effects have been unclear. Here, we identify FGF21 target cells in the hypothalamus and reveal that FGF21 signaling to glutamatergic neurons is both necessary and sufficient to mediate FGF21-induced sugar suppression and sweet-taste preference. Moreover, we show that FGF21 acts directly in the ventromedial hypothalamus (VMH) to specifically regulate sucrose intake, but not non-nutritive sweet-taste preference, body weight, or energy expenditure. Finally, our data demonstrate that FGF21 affects neuronal activity by increasing activation and excitability of neurons in the VMH. Thus, FGF21 signaling to glutamatergic neurons in the VMH is an important component of the neurocircuitry that functions to regulate sucrose intake.
机译：成纤维细胞生长因子21（FGF21）是由调节营养素和代谢稳态的肝脏产生的内分泌激素。响应于Macronourient的不平衡和向大脑的信号增加，产生FGF21的产量以抑制糖摄入和甜味偏好。然而，调解这些效果的中央目标尚不清楚。这里，我们鉴定下丘脑中的FGF21靶细胞，并揭示FGF21信号传导至谷氨酸神经元是必要的，并且足以介导FGF21诱导的糖抑制和甜味味道。此外，我们表明FGF21直接用腹侧下丘脑（VMH）起作用，以特异性调节蔗糖摄入，但不是非营养的甜味偏好，体重或能量消耗。最后，我们的数据表明FGF21通过增加VMH中神经元的激活和兴奋性来影响神经元活动。因此，VMH中的FGF21向谷氨酸神经元表示到谷氨酰胺神经元是神经速率的重要组成部分，其用于调节蔗糖摄入量。

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  • 来源
    《Cell metabolism》 |2020年第2期|共20页
  • 作者

    Jensen-Cody Sharon O.; Flippo Kyle H.; Claflin Kristin E.; Yavuz Yavuz; Sapouckey Sarah A.; Walters Grant C.; Usachev Yuriy M.; Atasoy Deniz; Gillum Matthew P.; Potthoff Matthew J.;

  • 作者单位

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

    Univ Copenhagen Sect Nutr &

    Metabolite Sensing Novo Nordisk Fdn Ctr Basic Metab Res DK-2200;

    Univ Iowa Carver Coll Med Dept Neurosci &

    Pharmacol Iowa City IA 52242 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 内分泌腺疾病及代谢病;
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