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首页> 外文期刊>Caries research >European Organization for Caries Research Workshop: Methodology for Determination of Potentially Available Fluoride in Toothpastes
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European Organization for Caries Research Workshop: Methodology for Determination of Potentially Available Fluoride in Toothpastes

机译：欧洲龋齿研究车间：测定牙养殖潜在氟化物的方法论

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Toothpastes are the most universally accepted form of fluoride delivery for caries prevention. To provide anti-caries benefits, they must be able to release fluoride during the time of tooth brushing or post brushing into the oral cavity. However, there is no standard accepted procedure to measure how much fluoride in a toothpaste may be (bio)available for release. The European Organization for Caries Research proposed and supported a workshop with experts in fluoride analysis in toothpastes and representatives from industry. The objective of the workshop was to discuss issues surrounding fluoride analysis in toothpaste and reach consensus on terminology and best practices, wherever the available evidence allowed it. Participants received a background paper and heard presentations followed by structured discussion to define the problem. The group also reviewed evidence on the validity, reliability and feasibility of each technique (namely chromatography and fluoride electroanalysis) and discussed their strengths and limitations. Participants were able to reach a consensus on terminology and were also able to identify and summarize the advantages and disadvantages of each technique. However, they agreed that most currently available methods were developed for regulatory agencies several decades ago, utilizing the best available data from clinical trials then, but require to be updated. They also agreed that although significant advances to our understanding of the mechanism of action of fluoride in toothpaste have been achieved over the past 4 decades, this clearly is an extraordinarily complex subject and more work remains to be done. (c) 2018 S. Karger AG, Basel
机译：牙膏是龋齿预防最普遍接受的氟化物递送形式。为了提供抗龋利益，它们必须能够在刷牙或刷入口腔时释放氟化物。然而，没有标准的接受程序可以测量牙膏中的氟化物（Bio）可用于释放。欧洲龋齿研究组织提出并支持了牙膏分析专家的研讨会，以及来自行业的代表。研讨会的目标是讨论牙膏中氟化物分析的问题，并在术语和最佳实践中达成共识，无论何处允许它。参与者收到了背景纸张和听到的演示文稿，然后是结构化讨论来定义问题。本集团还审查了有关每种技术的有效性，可靠性和可行性（即色谱和氟化物电）的有效性，可靠性和可行性的证据，并讨论了它们的优点和限制。参与者能够在术语上达成共识，也能够识别和总结每种技术的优缺点。然而，他们同意几十年前，几十年前正在为监管机构制定最新的方法，然后利用来自临床试验的最佳可用数据，但需要更新。他们还同意在过去的4年内实现了我们对牙膏中氟化物作用机制的理解，这显然是一个非常复杂的主题，更多的工作仍有待完成的工作。 （c）2018年S. Karger AG，巴塞尔

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