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Improvements in chemical carriers of proteins and peptides

机译：蛋白质和肽化学载体的改善

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Abstract The successful intracellular delivery of biologically active proteins and peptides plays an important role for therapeutic applications. Indeed, protein/peptide delivery could overcome some problems of gene therapy, for example, controlling the expression levels and the integration of transgene into the host cell genome. Thus, protein/peptide drug delivery showed a promising and safe approach for treatment of cancer and infectious diseases. Due to the unique physical and chemical properties of proteins, their production (e.g., isolation, purification & formulation) and delivery represented significant challenges in pharmaceutical studies. Modification in the structural moieties of these protein/peptide drugs could improve their solubility, stability, crystallinity, lipophilicity, enzymatic susceptibility and targetability, and subsequently, therapies and cures against various diseases. Using the structural modification of protein/peptide, their delivery provided overall higher success rates including high specificity, high activity, bioreactivity and safety. Recently, biotechnological and pharmaceutical companies have tried to find novel techniques for the modifications and improve delivery systems/carriers. However, each carrier has its own benefits and drawbacks, and an appropriate carrier is often established by the physicochemical properties of protein or peptide, the ideal route of injection, and clinical characteristics of therapy. In this review, an attempt was made to give an overview on the chemical carriers for proteins and peptides as well as the recent advances in this field.
机译：摘要生物活性蛋白质和肽的成功细胞内递送对治疗应用起重要作用。实际上，蛋白质/肽递送可以克服例如基因治疗的一些问题，例如，控制表达水平和转基因的整合到宿主细胞基因组中。因此，蛋白质/肽药物递送显示出对治疗癌症和传染病的有前途和安全的方法。由于蛋白质的独特物理和化学性质，它们的生产（例如，分离，纯化＆amp;制剂）和递送在药学研究方面具有重要挑战。这些蛋白质/肽药物的结构部分的改性可以改善它们的溶解度，稳定性，结晶度，亲脂性，酶促易感性和靶向性，以及随后对各种疾病的治疗和治愈。使用蛋白质/肽的结构改性，它们的递送提供了总体更高的成功率，包括高特异性，高活性，生物反应性和安全性。最近，生物技术和制药公司试图找到改进和改善交付系统/载体的新颖技术。然而，每个载体具有自己的益处和缺点，并且通常通过蛋白质或肽的物理化学性质，注射的理想途径和治疗的临床特征来确定合适的载体。在本综述中，试图概述蛋白质和肽的化学载体以及该领域最近的进展。

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