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首页> 外文期刊>Cell biology international. >Eph/ephrin family anchored on exosome facilitate communications between cells
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Eph/ephrin family anchored on exosome facilitate communications between cells

机译：Eph / Ephrin系列锚定外侧促进细胞之间的沟通

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摘要

Abstract Interactions of Ephrins and Eph receptors at cell membranes play crucial role in boundary formation and axon guidance. Extracellular vesicles (EVs), such as exosomes, are formed by cells communicating with each other in paracrine or endocrine manner. Until now, it is thought that direct cell–cell contact is necessary for ephrin and Eph receptor signal transduction. In this review, we discuss recent data that indicate the existence of a novel Eph‐ephrin family anchored exosome signaling pathway in long‐range intercellular communication and provide evidence that this type of signaling elicits cellular responses in cancer cells, independent of juxtacrine interactions. We emphasize that exosome‐anchored Eph/ephrin involves a variety of biological processes and transduction signals, which may serve as a potential diagnostic biomarker.
机译：摘要Ephrins和Eph受体在细胞膜中的相互作用在边界形成和轴突引导中起着至关重要的作用。 细胞外囊泡（例如外泌体）由细胞以旁碱或内分泌方式彼此连通的细胞形成。 到目前为止，据认为是Ephrin和Eph受体信号转导所需的直接细胞 - 细胞接触。 在该综述中，我们讨论了最近的数据，表明在远程细胞间通信中锚起了新的Eph-Ephrin系列的存在锚定外部信号通路，并提供了这种类型的信号传导在癌细胞中引发了癌细胞中的细胞反应，而与Juxtacrine相互作用无关。 我们强调外锚式Eph / Ephrin涉及各种生物过程和转导信号，其可以作为潜在的诊断生物标志物。

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  • 来源
    《Cell biology international.》 |2018年第11期|共5页
  • 作者

    Zhao Yao; Yin Lingyu; Zhang Haoliang; Lan Ting; Li Shibao; Ma Ping;

  • 作者单位

    School of Medical TechnologyXuzhou Medical UniversityXuzhou Jiangsu 221000 China;

    School of Medical TechnologyXuzhou Medical UniversityXuzhou Jiangsu 221000 China;

    School of Medical TechnologyXuzhou Medical UniversityXuzhou Jiangsu 221000 China;

    School of Medical TechnologyXuzhou Medical UniversityXuzhou Jiangsu 221000 China;

    School of Medical TechnologyXuzhou Medical UniversityXuzhou Jiangsu 221000 China;

    School of Medical TechnologyXuzhou Medical UniversityXuzhou Jiangsu 221000 China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    exosomes; Eph; ephrin; intercellular communication;

    机译：外泌体;Eph;Ephrin;细胞间通信;

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