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首页> 外文期刊>Cell biology international. >ox-LDL increases microRNA-29a transcription through upregulating YY1 and STAT1 in macrophages
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ox-LDL increases microRNA-29a transcription through upregulating YY1 and STAT1 in macrophages

机译：OX-LDL通过在巨噬细胞上的上调YY1和Stat1增加MicroRNA-29A转录

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摘要

Macrophages and oxidized low-density lipoprotein (ox-LDL) have been verified playing vital roles in the pathogenesis of atherosclerosis (AS). Previous studies demonstrated that microRNA-29a (miR-29a) was upregulated in many atherogenic process and cells, thus acting as an important participant in AS. But the detailed regulation mechanism of miR-29a in AS has not been fully understood. In our study, we demonstrated a positive feedback loop of ox-LDL-SRA-miR-29a. Furthermore, we found that YY1 and STAT1 were upregulated in ox-LDL-stimulating macrophages followed by translocation in the nucleus and binding to the transcriptional promoter region of miR-29a, thus leading to the increase of miR-29a expression. In addition, we demonstrated that JAK1/2 signaling was involved in miR-29a upregulation. Finally, we found that miR-29a played important roles in the secretion of proinflammation factors and lipid uptake in macrophages. We uncovered the molecular mechanism and provide novel insights into the function and regulatory network of miR-29a expression regulated by ox-LDL in macrophages.
机译：巨噬细胞和氧化的低密度脂蛋白（OX-LDL）已经过验证在动脉粥样硬化的发病机制（AS）的发病机制中起着重要作用。以前的研究证明，在许多致动脉粥样硬化过程和细胞中，将MicroRNA-29a（miR-29a）上调，因此作为重要参与者。但是，MIR-29A的详细调节机制尚未完全理解。在我们的研究中，我们展示了Ox-LDL-SRA-MIR-29A的正反馈回路。此外，我们发现YY1和STAT1在OX-LDL刺激的巨噬细胞中上调，然后在核中易位并与miR-29a的转录启动子区域结合，从而导致miR-29a表达的增加。此外，我们证明JAK1 / 2信号传导涉及MIR-29A上调。最后，我们发现miR-29a在巨噬细胞的分泌物分泌中发挥了重要作用和巨噬细胞的脂质吸收。我们发现了分子机制，并提供了对巨噬细胞中牛-LDL调节的miR-29a表达的功能和调节网络的新洞察。

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  • 来源
    《Cell biology international.》 |2017年第9期|共11页
  • 作者

    Jian Dongdong; Dai Bing; Hu Xiaotong; Yao Qiang; Zheng Chengfei; Zhu Jianhua;

  • 作者单位

    Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Cardiol Hangzhou 310003 Zhejiang Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Cardiol Hangzhou 310003 Zhejiang Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Intens Care Unit Hangzhou 310003 Zhejiang;

    Hangzhou Red Cross Hosp Dept Cardiol Hangzhou 310003 Zhejiang Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Cardiol Hangzhou 310003 Zhejiang Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Cardiol Hangzhou 310003 Zhejiang Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    macrophages; miR-29a; ox-LDL; STAT1; YY1;

    机译：巨噬细胞;miR-29a;ox-ldl;stat1;yy1;

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