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首页> 外文期刊>Cell and Tissue Research >The Lin28/let-7a/c-Myc pathway plays a role in non-muscle invasive bladder cancer
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The Lin28/let-7a/c-Myc pathway plays a role in non-muscle invasive bladder cancer

机译：Lin28 / Let-7A / C-Myc路径在非肌肉侵袭性膀胱癌中起作用

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摘要

We investigate the role of the Lin28/let-7a/c-Myc pathway in non-muscle invasive bladder cancer (NMIBC). Using RT-PCR, western blot and immunohistochemistry techniques, the levels of pre-let-7a, let-7a, Lin28 and c-Myc RNA and/or proteins were determined in samples of normal bladder tissue and bladder cancer. Expression of pre-let-7a was found to be negatively correlated with the pathological grade of bladder cancer, while let-7a showed a positive correlation with bladder cancer pathological grade. Expression of Lin28 RNA and protein was not significantly different between normal bladder tissue and low-grade transitional cell carcinoma of bladder (TCC) but the expression levels in high-grade TCC were remarkably increased. Expression of c-Myc RNA and protein was significantly higher in bladder cancer samples in comparison to normal bladder tissue without correlation with cancer differentiation. Expression of all the above RNAs and proteins showed no significant difference in Ta and T1 stages. The Lin28/let-7a/c-Myc pathway plays an important role in NMIBC. In particular, expression levels of let-7a correlate with the degree of cancer differentiation but not cancer stage.
机译：我们调查Lin28 / Let-7A / C-Myc路径在非肌肉侵入性膀胱癌（NMIBC）中的作用。使用RT-PCR，Western印迹和免疫组织化学技术，在正常膀胱组织和膀胱癌的样品中测定预诱剂-7a，Let-7a，Lin28和C-myc RNA和/或蛋白质的水平。发现预诱导7A的表达与膀胱癌的病理等级负相关，而Let-7a显示出与膀胱癌病理等级的正相关性。碱膀胱组织和膀胱低级过渡细胞癌之间的表达没有显着差异（TCC），但高级TCC的表达水平显着增加。膀胱癌样品中C-Myc RNA和蛋白的表达明显高于与癌症分化相关的正常膀胱组织。所有上述RNA和蛋白质的表达显示出TA和T1阶段没有显着差异。 Lin28 / Let-7A / C-Myc路径在NMIBC中起重要作用。特别地，Let-7a的表达水平与癌症分化程度相关但不是癌症阶段。

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  • 来源
    《Cell and Tissue Research》 |2013年第2期|共9页
  • 作者

    LiY.; LiuH.; LaiC.; DuX.; SuZ.; GaoS.;

  • 作者单位

    Department of Urology First Affiliated Hospital Jinan University Avenue West 601 Guangzhou;

    Guangdong Women and Children Hospital Guangzhou Guangdong 511400 China;

    Department of Urology First Affiliated Hospital Jinan University Avenue West 601 Guangzhou;

    Department of Urology First Affiliated Hospital Jinan University Avenue West 601 Guangzhou;

    Department of Urology First Affiliated Hospital Jinan University Avenue West 601 Guangzhou;

    Department of Pathology Yuebei People's Hospital Shaoguan Guangdong 512026 China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    c-Myc; let-7a; Lin28; miRNA; Non-muscle invasive bladder cancer;

    机译：c-myc;let-7a;lin28;miRNA;非肌肉侵袭性膀胱癌;

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