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Toolbox in a tadpole: Xenopus for kidney research

机译：Tadpole的工具箱：肾病研究的Xenopus

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摘要

Xenopus is a versatile model organism increasingly used to study organogenesis and genetic diseases. The rapid embryonic development, targeted injections, loss- and gain-of-function experiments and an increasing supply of tools for functional in vivo analysis are unique advantages of the Xenopus system. Here, we review the vast array of methods available that have facilitated its transition into a translational model. We will focus primarily on how these methods have been employed in the study of kidney development, renal function and kidney disease. Future advances in the fields of genome editing, imaging and quantitative 'omics approaches are likely to enable exciting and novel applications for Xenopus to deepen our understanding of core principles of renal development and molecular mechanisms of human kidney disease. Thus, using Xenopus in clinically relevant research diversifies the narrowing pool of "standard" model organisms and provides unique opportunities for translational research.
机译：宫府是一种多功能模型生物，越来越多地用于研究心房发生和遗传疾病。快速的胚胎发育，有针对性的注射，丧失和功能性实验以及越来越多的体内分析工具供应是外爪座系统的独特优势。在这里，我们审查了大量可用的方法，这些方法促进了转换到翻译模型。我们将主要集中在肾发育，肾功能和肾病研究中如何使用这些方法。关于基因组编辑，成像和定量的“OMICS方法”领域的未来进展很可能为南欧省开始令人兴奋和新的应用，以加深我们对人肾病的肾发展核心原则和分子疾病的理解。因此，在临床相关研究中使用外爪us使“标准”模型生物的缩小池分开，并为翻译研究提供独特的机会。

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