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Using Drosophila nephrocytes in genetic kidney disease

机译:在遗传肾疾病中使用果蝇肾腺细胞

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摘要

Renal diseases are a growing health burden, and innovative models to study their pathomechanisms are greatly needed. Here, we highlight how the fruit fly Drosophila melanogaster can be used to model kidney diseases. We focus on the nephrocyte that has recently been shown to exhibit podocyte and proximal tubular cell features. These cells can be manipulated with precise genetic tools to dissect filtration and reabsorption mechanisms. Thus, they represent a novel and easy-to-use alternative in experimental nephrology.
机译:肾病是一种不断增长的健康负担,并且大大需要创新的型号来研究他们的理由。 在这里,我们突出了果蝇果蝇Melanogaster如何用于模拟肾病的方式。 我们专注于最近显示出现过孔细胞和近端管状细胞特征的肾细胞。 可以用精确的遗传工具操纵这些细胞以筛选过滤和重吸收机制。 因此,它们代表了实验性肾脏的新颖且易于使用的替代品。

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