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Three-dimensional fine structure of the organization of microtubules in neurite varicosities by ultra-high voltage electron microscope tomography

机译：超高压电子显微镜断层扫描的神经沸石污染物组织三维精细结构

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摘要

Neurite varicosities are highly specialized compartments that are involved in neurotransmitter/ neuromodulator release and provide a physiological platform for neural functions. However, it remains unclear how microtubule organization contributes to the form of varicosity. Here, we examine the three-dimensional structure of microtubules in varicosities of a differentiated PC12 neural cell line using ultra-high voltage electron microscope tomography. Three-dimensional imaging showed that a part of the varicosities contained an accumulation of organelles that were separated from parallel microtubule arrays. Further detailed analysis using serial sections and whole-mount tomography revealed microtubules running in a spindle shape of swelling in some other types of varicosities. These electron tomographic results showed that the structural diversity and heterogeneity of microtubule organization supported the form of varicosities, suggesting that a different distribution pattern of microtubules in varicosities is crucial to the regulation of varicosities development.
机译：神经晶含有的含量是神经递质/神经调节剂释放的高度专业的隔室，并为神经功能提供生理平台。然而，仍然尚不清楚Microtubule组织如何促进含量的形式。这里，我们使用超高压电子显微镜断层扫描检查分化的PC12神经细胞系的致异数中微管的三维结构。三维成像表明，一部分含有的含有细胞器的积聚，其与平行微管阵列分离。使用串行部分和全挂成像摄影的进一步详细分析显示了在一些其他类型的污物中膨胀的主轴形状中运行的微管。这些电子断层摄影结果表明，微管组织的结构多样性和异质性支持致血清的形式，表明在致异数中的微管的不同分布模式对于调节变异发育来说至关重要。

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