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首页> 外文期刊>Cell and Tissue Research >Role of TGF-beta in metastatic colon cancer: it is finally time for targeted therapy
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Role of TGF-beta in metastatic colon cancer: it is finally time for targeted therapy

机译：TGF-β在转移性结肠癌中的作用：终于靶向治疗的时间

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摘要

Colorectal cancer (CRC) is one of the most frequent tumor types in Western countries. Approximately 20% of patients show metastasis at the time of diagnosis, with the liver being one of the most affected organs. Transforming growth factor-beta (TGF-beta) plays a regulatory role not only in the physiology of the normal colon but also in the development of CRC and its metastatic process. In this review, we analyze the molecular mechanisms leading to TGF-beta dysregulation in tumor and stroma cells and the modification of the microenvironment that fosters CRC metastasis. Recent genomic studies have identified a CRC subtype with a mesenchymal and aggressive phenotype having TGF-beta as a hub gene of this signature. Consistent with these findings, the inhibition of TGF-beta signaling has been shown to impair experimental CRC metastasis to the liver. Based on these and other results conducted in various tumor types, the pharmaceutical industry has developed a variety of strategies to target TGF-beta. We provide up-to-date information of these therapies, which are currently in preclinical or clinical trials.
机译：结肠直肠癌（CRC）是西方国家最常见的肿瘤类型之一。大约20％的患者在诊断时显示转移，肝脏是受影响最严重的器官之一。转化生长因子-β（TGF-Beta）不仅在正常结肠的生理学中起着监管作用，而且在CRC的发展和转移过程中发挥了监管作用。在该综述中，我们分析了肿瘤和基质细胞中TGF-β失调的分子机制以及促进CRC转移的微环境的修饰。最近的基因组研究已经鉴定了具有间充质和具有TGF-β作为该签名的集线基因的CRC亚型。与这些发现一致，已显示抑制TGF-β信令损害实验CRC转移到肝脏。基于各种肿瘤类型进行的这些和其他结果，制药行业已开发出各种策略来靶向TGF-β。我们提供这些疗法的最新信息，目前正在临床或临床试验中。

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