...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >PAD2 overexpression in transgenic mice augments malignancy and tumor-associated inflammation in chemically initiated skin tumors
【24h】

PAD2 overexpression in transgenic mice augments malignancy and tumor-associated inflammation in chemically initiated skin tumors

机译：转基因小鼠中的乳头2过表达增强了化学发起的皮肤肿瘤中的恶性肿瘤和肿瘤相关的炎症

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We previously found that transgenic mice overexpressing MMTV-FLAG-hPAD2 (PAD2OE) developed spontaneous skin lesions, with a subset of these lesions progressing to invasive squamous cell carcinoma (SCC). The goal of this report was to better understand the potential mechanisms by which PAD2 overexpression promotes skin cancer. Here, PAD2OE mice were treated with the carcinogen, 9,10-dimethyl-1,2-benzanthracene and with O-tetradecanoylphorbol-13-acetate and then scored for papilloma formation. Additionally, tumor sections were evaluated for evidence of tumor cell invasion and inflammation. We found that the total number of papillomas was significantly increased in PAD2OE mice compared to controls. Histopathologic analysis of the lesions found that in PAD2OE skin tumors progressed to invasive SCC more frequently than controls. Additionally, we found that PAD2OE lesions were highly inflamed, with a dense inflammatory cell infiltrate and an associated increase in nuclear phospho-STAT3 (signal transducer and activator of transcription 3) in the transgenic tumors. These data suggest that overexpression of the hPAD2 transgene in the epidermis increases the malignant conversion rate of benign tumors by promoting an inflammatory microenvironment.
机译：我们之前发现过表达MMTV-Flag-HPAD2（PAD2OE）的转基因小鼠开发了自发性皮肤病变，这些病变的子集进展到侵袭性鳞状细胞癌（SCC）。本报告的目标是更好地了解PAD2过表达促进皮肤癌的潜在机制。这里，用致癌癌，9,10-二甲基-1,2-苯并丙烯丙烯和用O-四癸酰卟啉-13-乙酸盐处理帕氏乳酪小鼠，然后用于乳头状瘤形成。另外，评估肿瘤切片以证明肿瘤细胞侵袭和炎症。我们发现，与对照相比，PAD2Oe小鼠中乳头瘤的总数显着增加。病变的组织病理学分析发现，在PAD2oe皮肤肿瘤中，进展比对照更频繁地侵入SCC。此外，我们发现PAD2OE病变高度发炎，具有致密炎症细胞浸润和在转基因肿瘤中核磷-TAT3（信号传感器和转录3的信号传感器和转移剂3）的相关增加。这些数据表明，通过促进炎症微环境，表皮中HPAD2转基因的过度表达增加了良性肿瘤的恶性转化率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号