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首页> 外文期刊>Cell and Tissue Research >Intestinal macrophages in Peyer's patches, sacculus rotundus and appendix of Angora rabbit
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Intestinal macrophages in Peyer's patches, sacculus rotundus and appendix of Angora rabbit

机译：Peyer的肠道巨噬细胞，Sacculus Rotundus和Angora Rabbit附录

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The largest pool of macrophages in the body is harboured by the intestinal mucosa. As the principal phagocytic component of the immune system, macrophages are essential for maintaining mucosal homeostasis as they prevent commensal bacteria from adhering to mucosal epithelial cells. This study provides a RAM11 immunohistochemical and electron microscopic investigation of the existence, localization and distribution of intestinal macrophages in organized gut-associated lymphoid tissue (GALT), including Peyer's patches (PPs), the sacculus rotundus (SR) and the appendix, in the Angora rabbit. Although rabbit intestinal macrophages did not express the tissue macrophage marker macrosialin (CD68), they expressed RAM11. RAM11-positive intestinal macrophages were mostly localized to the subepithelial dome region, interfollicular area and germinal centres (GCs) of the GALT and the lamina propria or submucosa of the ileum and jejunum devoid of PPs and were also observed in the follicle-associated epithelium of PPs, but not in that of the SR and appendix. RAM11-positive macrophages containing engulfed apoptotic bodies were present in the GCs of the lymphoid follicles in the GALT. Electron microscopy further revealed multiple macrophages containing apoptotic bodies within the GCs of the follicles in the GALT. Some macrophage aggregations were observed in the GC and between the GC and the corona region of the follicles in the SR and appendix. Rabbit intestinal macrophages thus undertake both potent phagocytic activity and the efficient scavenging of apoptotic cells. Immunohistochemical data suggest that RAM11 can be reliably used for the determination of intestinal macrophages in the GALT of rabbits.
机译：身体中最大的巨噬细胞池被肠粘膜覆盖。作为免疫系统的主要吞噬成分，巨噬细胞对于维持粘膜稳定性的巨噬细胞是必不可少的，因为它们可以防止共生细菌粘附在粘膜上皮细胞上。本研究为有组织的肠道相关淋巴组织（GALT）中的肠巨噬细胞的存在，定位和分布提供了RAM11免疫组化和电子显微镜调查，包括PEYER的贴片（PPS），Sacculus Rotundus（SR）和附录中的肠道巨噬细胞安哥拉兔子。虽然兔肠巨噬细胞没有表达组织巨噬细胞标志物宏观素（CD68），但它们表达了RAM11。 Ram11-阳性肠巨噬细胞主要是局部地定位的GALT的亚斯皮目齐毕圆顶区域，与薄荷和JEJUNUM的椎板和粘膜桩或缺乏PPS的毛细血管，并且在卵泡相关的上皮中也观察到PPS，但不是在SR和附录中。含有吞噬凋亡体的Ram11阳性巨噬细胞存在于GALT中淋巴卵泡的GCS中。电子显微镜进一步揭示了在GALT中卵泡的GCS内含有凋亡体的多种巨噬细胞。在GC和GC与SR和附录中的卵泡的GC和Corona区之间观察到一些巨噬细胞聚集。因此，兔肠道巨噬细胞既有有效的吞噬活性和凋亡细胞的有效清除。免疫组织化学数据表明RAM11可以可靠地用于测定兔GATT中的肠巨噬细胞。

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