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首页> 外文期刊>Cell and Tissue Research >Distinct hormonal regulation of two types of sexual dimorphism in submandibular gland of mice
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Distinct hormonal regulation of two types of sexual dimorphism in submandibular gland of mice

机译：小鼠颌下腺中两种性别二态性的明显激素调节

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The submandibular gland (SMG) of mice exhibits prominent sexual dimorphism in two aspects: the preferential development of granular convoluted tubule (GCT) cells and the earlier disappearance of granular intercalated duct (GID) cells in males after puberty. The former is dependent on androgens and thyroid hormones, whereas the hormonal dependence of the latter remains obscure. In the present study, we examined the effects of the postnatal administration of androgens and thyroid hormones to wild-type (WT) and androgen-receptor-knockout (ARKO) mice on these two types of sexual dimorphism by counting the numbers of GCT and GID cells labeled with nerve growth factor and submandibular gland protein C, respectively, as immunohistochemical markers. WT females and ARKO males and females exhibited a lower number of GCT cells and higher number of GID cells at 5 and 11 weeks postpartum than WT males. The administration of dihydrotestosterone for 1-2 weeks prior to these ages caused an increase in GCT cells and decrease in GID cells in WT females to similar levels as those in WT males, whereas it had no effects in ARKO, indicating that both types of sexual dimorphism are androgen-dependent. In contrast, the administration of thyroxine caused an increase in GCT cells but did not cause a decrease in GID cells in WT females or ARKO, indicating that the former is dependent on thyroid hormones, whereas the latter is not. The present results suggest that the two types of sexual dimorphism in the mouse SMG undergo distinct forms of hormonal regulation and, therefore, have different mechanisms.
机译：小鼠的颌下腺（SMG）在两个方面表现出突出的性二态：粒状复合小管（GCT）细胞的优先发展和青春期后雄性颗粒插入管道（GID）细胞的早期消失。前者依赖于雄激素和甲状腺激素，而后者的荷尔蒙依赖仍然是模糊的。在本研究中，通过计数GCT和GID的数量，我们研究了雌激素和甲状腺激素的出生和甲状腺激素对野生型（WT）和雄激素受体 - 敲除（Arko）小鼠的影响分别用神经生长因子和颌下腺蛋白C标记的细胞，作为免疫组化标志物。 WT女性和arko男性和女性在产后的5和11周的较低的GCT细胞和较多的GIT细胞数量比wt雄性呈现。在这些年龄之前1-2周给药1-2周导致GCT细胞增加，并且WT女性的胶质细胞减少与WT男性相似的水平，而它在Arko中没有任何影响，表明这两种类型的性行为二形是雄激素依赖性。相反，甲状腺素的给药导致GCT细胞增加，但没有导致WT女性或Arko中的GID细胞减少，表明前者依赖于甲状腺激素，而后者则不依赖于甲状腺激素。目前的结果表明，小鼠SMG中的两种类型的性二晶态经历了不同的激素调节形式，因此具有不同的机制。

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