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Native tissue-based strategies for meniscus repair and regeneration

机译：用于弯月面修复和再生的本机基于组织的策略

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摘要

Meniscus injuries appear to be becoming increasingly common and pose a challenge for orthopedic surgeons. However, there is no curative approach for dealing with defects in the inner meniscus region due to its avascular nature. Numerous strategies have been applied to regenerate and repair meniscus defects and native tissue-based strategies have received much attention. Native tissue usually has good biocompatibility, excellent mechanical properties and a suitable microenvironment for cellular growth, adhesion, redifferentiation, extracellular matrix deposition and remodeling. Classically, native tissue-based strategies for meniscus repair and regeneration are divided into autogenous and heterogeneous tissue transplantation. Autogenous tissue transplantation is performed more widely than heterogeneous tissue transplantation because there is no immunological rejection and the success rates are higher. This review first discusses the native meniscus structure and function and then focuses on the use of the autogenous tissue for meniscus repair and regeneration. Finally, it summarizes the advantages and disadvantages of heterogeneous tissue transplantation. We hope that this review provides some suggestions for the future design of meniscus repair and regeneration strategies.
机译：半月板伤害似乎越来越普遍，对整形外科医生构成挑战。然而，由于其缺血性质，没有用于处理内半月板区域的缺陷的治疗方法。已经应用了许多策略来再生和修复弯月面缺陷，并且本土组织的策略受到了很多关注。本地组织通常具有良好的生物相容性，优异的机械性能和用于细胞生长，粘附，再分析，细胞外基质沉积和重塑的合适的微环境。经典地，弯月球修复和再生的本机基于组织的策略分为自源性和异质组织移植。性和组织移植的性能比异质组织移植更广泛地进行，因为没有免疫抑制，并且成功率更高。本综述首先讨论了本地弯月面结构和功能，然后专注于使用自生组织进行弯月面修复和再生。最后，总结了异质组织移植的优缺点。我们希望本综述为未来的半月板修复和再生策略提供了一些建议。

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  • 来源
    《Cell and Tissue Research》 |2018年第2期|共14页
  • 作者

    Zhang Zengzeng; Guo Weimin; Gao Shuang; Chen Mingxue; Li Xu; Zhang Xueliang; Jing Xiaoguang; Wang Mingjie; Zhang Yu; Shen Shi; Wang Zehao; Sun Baichuan; Chai Ying; Zhou Chengfu; Liu Shuyun; Guo Quanyi;

  • 作者单位

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Peking Univ Acad Adv Interdisciplinary Studies Ctr Biomat &

    Tissue Engn Beijing 100871 Peoples;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Nankai Univ Sch Med Tianjin 300071 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Jiamusi Univ Affiliated Hosp 1 Jiamusi 154002 Peoples R China;

    Jiamusi Univ Affiliated Hosp 1 Jiamusi 154002 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

    Chinese Peoples Liberat Army Gen Hosp Inst Orthoped Beijing 100853 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Native tissue; Meniscus; Tissue repair and regeneration; Autogenous tissue transplantation; Heterogeneous tissue transplantation;

    机译：本地组织;弯月面;组织修复和再生;自生组织移植;异质组织移植;

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