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首页> 外文期刊>Cell and Tissue Research >Structural and molecular characteristics of axons in the long head of the biceps tendon
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Structural and molecular characteristics of axons in the long head of the biceps tendon

机译：二头肌肌腱长头轴突的结构和分子特征

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摘要

The innervation of the long head of the biceps tendon (LHBT) is not sufficiently documented. This is a drawback since pathologies of the LHBT are a major source of shoulder pain. Thus, the study aimed to characterize structurally and molecularly nervous elements of the LHBT. The proximal part of 11 LHBTs was harvested intraoperatively. There were 8 female and 3 male specimens. Age ranged from 66 to 86 years. For structural analyses, nervous elements were viewed in the transmission electron microscope. For molecular characterization, we used general neuronal markers including antibodies against neurofilament and protein gene product 9.5 (PGP9.5) as well as specific neuronal markers including antibodies against myelin basic protein (MBP), calcitonin gene-related product (CGRP), substance P (SP), tyrosine hydroxylase (TH), and growth-associated protein 43 (GAP43). Anti-neurofilament and anti-PGP9.5 visualized the overall innervation. Anti-MBP visualized myelination, anti-CGRP and anti-SP nociceptive fibers, anti-TH sympathetic nerve fibers, and anti-GAP43 nerve fibers during development and regeneration. Immunolabeled sections were analyzed in the confocal laser scanning microscope. We show that the LHBT contains unmyelinated as well as myelinated nerve fibers which group in nerve fascicles and follow blood vessels. Manny myelinated and unmyelinated axons exhibit molecular features of nociceptive nerve fibers. Another subpopulation of unmyelinated axons exhibits molecular characteristics of sympathetic nerve fibers. Unmyelinated sympathetic fibers and unmyelinated nociceptive fibers express proteins that are found during development and regeneration. Present findings support the hypothesis that ingrowth of nociceptive fibers are the source of chronic tendon pain.
机译：二头肌肌腱长头（LHBT）的支配不充分记录。这是由于LHBT的病理是肩痛的主要来源。因此，研究旨在表征在结构上和分子神经元素的LHBT。术中收获11 LHBT的近端部分。有8名女性和3个男性标本。年龄范围从66到86岁。对于结构分析，在透射电子显微镜中观察神经元素。用于分子表征，我们使用包括针对神经膜和蛋白质基因产物9.5（PGP9.5）的抗体的一般神经元标记，以及特定的神经元标记，包括针对髓鞘碱性蛋白（MBP），降钙素基因相关产品（CGRP），物质P.物质P. （SP），酪氨酸羟化酶（TH）和生长相关蛋白43（GAP43）。抗神经丝和抗PGP9.5可视化整体内脏。抗MBP可视化的髓鞘，抗CGRP和抗SP伤害纤维，抗-IMPathetic神经纤维和抗GAP43神经纤维在发育和再生过程中。在共聚焦激光扫描显微镜中分析免疫标签部分。我们表明，LHBT含有未封面的和肌肉神经纤维，其中在神经束和伴随血管中进行群体。 Manny Myelinated和未封闭的轴突表现出伤害神经纤维的分子特征。未封闭的轴突的另一个亚群表现出交感神经纤维的分子特征。未键入的交感神经纤维和未键入的伤害纤维在发育和再生过程中发现的蛋白质。目前的调查结果支持伤害纤维的发起的假设是慢性肌腱疼痛的来源。

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