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首页> 外文期刊>Cell and Tissue Research >Immune-associated renal disease found in caspase 3-deficient mice
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Immune-associated renal disease found in caspase 3-deficient mice

机译：在Caspase 3缺陷小鼠中发现免疫相关的肾病

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Caspase (CASP) 3 is known as a representative effector CASP of apoptosis and recently as a mediator in inflammatory cell death called pyroptosis. Interestingly, homozygotes of Casp3 knockout (KO) mice with 129-background show complete embryonic lethality; however, some of those with C57BL/6 (B6)-background (B6.129S1-Casp3(tm1Flv)/J) survived at a lower rate (KO, 11%; WT, 22%), developing immune abnormality-associated renal phenotypes. Homozygotes of Casp3 KO mice with B6-background that survived for 8-12 months showed abnormality in the kidney and spleen but not in other organs. Briefly, these Casp3 KO kidneys showed proliferative glomerular lesions characterized by increased cells, matrices, immune complex depositions containing IgA and complement 3 in the mesangial area, podocyte injuries and inflammatory cell infiltrations in the tubulointerstitium. However, severe membranous lesion or renal dysfunction was not observed. Increased expression of inflammation-associated gene sets and inflammatory Casps, including Casp12, was observed in these Casp3 KO kidneys. Moreover, these Casp3 KO mice showed mild splenomegaly compared with WT mice. Thus, the long-surviving Casp3 KO mice with B6-background developed renal lesions with altered immune conditions. CASP3 deficiency and aging factors could affect this phenotype by altering the function and/or development of each cell in the kidney and immune organs.
机译：Caspase（Casp）3被称为细胞凋亡的代表性效应Casp，最近作为炎症性细胞死亡的介质，称为γ凋亡。有趣的是，Casp3敲除（KO）小鼠的纯合子与129次背景显示完全胚胎致死态;但是，其中一些有C57BL / 6（B6）-Background（B6.129S1-CASP3（TM1FLV）/ J）以较低的速率（KO，11％; WT，22％），产生免疫异常相关的肾表型。 Casp3 Ko小鼠的纯合子与B6背景，滋生8-12个月在肾脏和脾脏中出现异常，但不在其他器官中。简而言之，这些Casp3 KO肾脏显示出具有含有IgA的细胞，基质，免疫复合物沉积的增殖性肾小球病变，含有IgA和含有IgA的补体3，细胞孔损伤和微管中的炎症细胞浸润。然而，未观察到严重的膜病变或肾功能障碍。在这些Casp3 KO肾脏中观察到炎症相关基因集和包括Casp12，包括Casp12的炎症患者的表达。此外，与WT小鼠相比，这些Casp3 Ko小鼠显示了轻度脾肿大。因此，具有B6背景的长潜逃的Casp3 KO小鼠具有改变的免疫条件发生了肾病。通过改变肾脏和免疫器官中每种细胞的功能和/或开发，Casp3缺乏症和老化因子可能影响这种表型。

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