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Urocortins and their unfolding role in mammalian social behavior

机译:尿道素及其在哺乳动物社会行为中的作用

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The corticotropin-releasing factor (CRF) system is well known for its major role in coordinating the endocrine, autonomic and behavioral responses to stress. These functions have been shown to be mediated mainly by the binding of the CRF neuropeptide to its specific receptor CRFR1. Yet, the CRF system comprises several more neuropeptides, including the three urocortins, UCN1, UCN2 and UCN3, of which the latter two bind specifically to a distinct receptorCRFR2. Unlike the brain-wide abundant expression of CRF and CRFR1, the brain expression of the urocortins and CRFR2 is rather restricted and seems to be focused in limbic areas associated with social behavior. Here, we will review accumulating evidence from recent studies that unfold the role of UCN2 and UCN3 in regulating mammalian social behavior, via activation of CRFR2.
机译:释放因子(CRF)系统(CRF)系统是众所周知的,其在协调内分泌,自主和行为对压力的行为反应方面具有重要作用。 已经显示这些功能主要通过CRF神经肽与其特异性受体CRFR1的结合来介导。 然而,CRF系统包含几种更多的神经肽,包括三个尿道素,UCN1,UCN2和UCN3,后者两者特异性地结合到不同的受体克2。 与CRF和CRFR1的脑宽丰富表达不同,尿道素和CRFR2的脑表达相当受到限制,似乎专注于与社会行为相关的居瘫区。 在这里,我们将通过激活CRFR2,从最近的研究中审查来自最近的研究中的累积证据,以展开UCN2和UCN3在调节哺乳动物社会行为方面的作用。

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