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首页> 外文期刊>Acta oncologica. >Early prediction of pathological response in locally advanced rectal cancer based on sequential 18F-FDG PET
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Early prediction of pathological response in locally advanced rectal cancer based on sequential 18F-FDG PET

机译：基于连续18F-FDG PET的局部晚期直肠癌病理反应的早期预测

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Background. The objectives of this study were to investigate the predictive value of sequential 18F-FDG PET scans for pathological tumor response grade (TRG) after preoperative chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC) and the impact of partial volume effects correction (PVC). Methods. Twenty-eight LARC patients were included. Responders and non-responders status were determined in histopathology. PET indices [SUV max and mean, volume and total lesion glycolysis (TLG)] at baseline and their evolution after one and two weeks of PCRT were extracted by delineation of the PET images, with or without PVC. Their predictive value was investigated using Mann-Whitney-U tests and ROC analysis. Results. Within baseline parameters, only SUVmean was correlated with response. No evolution after one week was predictive of the response, whereas after two weeks all the parameters except volume were, the best prediction being obtained with TLG (AUC 0.79, sensitivity 63%, specificity 92%). PVC had no significant impact on these results. Conclusion. Several PET indices at baseline and their evolution after two weeks of PCRT are good predictors of response in LARC, with or without PVC, whereas results after one week are suboptimal. Best predictor was TLG reduction after two weeks, although baseline SUVmean had smaller but similar predictive power.
机译：背景。这项研究的目的是调查连续18F-FDG PET扫描对局部晚期直肠癌（LARC）术前放化疗后（PCRT）病理病理反应等级（TRG）的预测价值以及部分体积效应校正（PVC）的影响）。方法。包括28名LARC患者。在组织病理学中确定了反应者和非反应者的状态。通过描绘PET图像（带或不带PVC），提取基线时的PET指数[SUV最大值，平均值，体积和总损伤糖酵解（TLG）]及其在PCRT一两周后的演变。使用Mann-Whitney-U检验和ROC分析研究了它们的预测价值。结果。在基线参数范围内，只有SUVmean与反应相关。一周后无进展可预测反应，而两周后除体积外所有参数均达到最佳预测（TLC为AUC 0.79，敏感性为63％，特异性为92％）。 PVC对这些结果没有重大影响。结论。 PCRT两周后，基线时的几个PET指数及其演变是有或无PVC的LARC中反应良好的预测指标，而一周后的结果则不是最佳。最佳预测指标是两周后TLG降低，尽管基线SUVmean的预测力较小但相似。

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