Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells

Lork Marie; Staal Jens; Beyaert Rudi

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Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells

机译：在T细胞中持续的CARD11-BCL10-MALT1信号组的泛素化和磷酸化

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Antigen receptor-induced signaling plays an important role in inflammation and immunity. Formation of a CARD11-BCL10-MALT1 (CBM) signaling complex is a key event in T- and B cell receptor-induced gene expression by regulating NF-kappa B activation and mRNA stability. Deregulated CARD11, BCL10 or MALT1 expression or CBM signaling have been associated with immunodeficiency, autoimmunity and cancer, indicating that CBM formation and function have to be tightly regulated. Over the past years great progress has been made in deciphering the molecular mechanisms of assembly and disassembly of the CBM complex. In this context, several posttranslational modifications play an indispensable role in regulating CBM function and downstream signal transduction. In this review we summarize how the different CBM components as well as their interplay are regulated by protein ubiquitination and phosphorylation in the context of T cell receptor signaling.

机译：抗原受体诱导的信号传导在炎症和免疫中起重要作用。 CARD11-BCL10-MALT1（CBM）信号络合物的形成是通过调节NF-Kappa B激活和mRNA稳定性的T-和B细胞受体诱导的基因表达的关键事件。 Derocation Card11，BCL10或MALT1表达或CBM信号传导与免疫缺陷，自身免疫和癌症有关，表明CBM形成和功能必须严格调节。在过去几年中，在解密CBM复合物的分子机制和拆卸的分子机制方面取得了很大进展。在这种情况下，几种后期后修改在调节CBM功能和下游信号转导方面发挥不可或缺的作用。在本次综述中，我们总结了在T细胞受体信号传导的背景下的蛋白质泛素化和磷酸化的不同CBM组分以及它们的相互作用。

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《Cellular immunology》 |2019年第2019期|共15页
作者
Lork Marie; Staal Jens; Beyaert Rudi;
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作者单位

Univ Ghent Dept Biomed Mol Biol Ghent Belgium;

Univ Ghent Dept Biomed Mol Biol Ghent Belgium;

Univ Ghent Dept Biomed Mol Biol Ghent Belgium;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
T cells; Lymphocytes; CARD11; MALT1; BCL10; Ubiquitin; Phosphorylation; Inflammation; Immunity; NF-kappa B;

机译：T细胞;淋巴细胞;卡11;MALT1;BCL10;泛素;磷酸化;炎症;免疫;NF-Kappa B;

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专利

1. Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells [J] . Lork Marie, Staal Jens, Beyaert Rudi Cellular immunology . 2019,第期

机译：在T细胞中持续的CARD11-BCL10-MALT1信号组的泛素化和磷酸化
2. Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation. [J] . Zhu F, Zykova TA, Peng C, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2011,第2期

机译：H2AX在Ser139处的磷酸化和RSK2产生的新的磷酸化位点Ser16降低了H2AX泛素化并抑制细胞转化。
3. T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component [J] . Claudia Brockmeyer, Wolfgang Paster, David Pepper, The Journal of biological chemistry . 2011,第9期

机译：T细胞受体（TCR）引起的酪氨酸磷酸化动力学将其鉴定为新的TCR信号组组分
4. Characterizing Phosphorylation and Ubiquitination Cross-talk in Magnaporthe oryzae [C] . Jennifer Parker, Yeonyee Oh, Ralph A. Dean, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：表征磷酸化磷酸化和泛骨互相串扰
5. Molecular mechanism of inhibitor of kappa B kinase (IKK) complex activation by inducible phosphorylation and ubiquitination upon T cell receptor (TCR) stimulation. [D] . Shambharkar, Prashant. 2007

机译：在T细胞受体（TCR）刺激下，可诱导的磷酸化和泛素化作用抑制kappa B激酶（IKK）复合物激活的分子机制。
6. The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency [O] . Stuart E Turvey, Anne Durandy, Alain Fischer, -1

机译：CARD11-BCL10-MALT1（CBM）信号小体复合物：成为人类主要免疫缺陷的焦点
7. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. [O] . Brockmeyer, C, Paster, W, Pepper, D, 2011

机译：T细胞受体（TCR）诱导的酪氨酸磷酸化动力学确定THEMIS为新的TCR信号体成分。

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells

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