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首页> 外文期刊>Cellular immunology >Generation and functional assessment of nonhuman primate regulatory dendritic cells and their therapeutic efficacy in renal transplantation
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Generation and functional assessment of nonhuman primate regulatory dendritic cells and their therapeutic efficacy in renal transplantation

机译：非人类灵长类动物调节性树突细胞的生成和功能评估及肾移植治疗疗效

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摘要

Nonhuman primates (NHP) are important pre-clinical models for evaluation of the safety and efficacy of the most promising potential therapeutic advances in organ transplantation based on rodent studies. Although rare, dendritic cells (DC) play important roles in preservation of self tolerance and DC with immunoregulatory properties (regulatory DC; DCreg) can promote transplant tolerance in rodents when adoptively transferred to allograft recipients. NHP DCreg can be generated ex vivo from bone marrow precursors or blood monocytes of cynomolgus or rhesus macaques or baboons. NHP DCreg generated in the presence of anti-inflammatory factors that confer stability and resistance to maturation, subvert alloreactive T cell responses. When infused into rhesus renal allograft recipients before transplant, they safely prolong MHC mis-matched graft survival, associated with attenuation of anti-donor immune reactivity. In this concise review we describe the properties of NHP DCreg and discuss their influence on T cell responses, alloimmunity and organ transplant survival.
机译：非人的灵长类动物（NHP）是评估基于啮齿动物研究的器官移植最有希望的潜在治疗进展的安全性和功效的重要临床模型。虽然罕见的树突状细胞（DC）在保存自我耐受性和DC具有免疫调节性质（调节DC; DCREG）的情况下起重要作用，但是在养护于同种异体移植受者转移到同种异体移植受者时可以促进啮齿动物的移植耐受性。 NHP DCREG可以从骨髓前体或血清瘤或恒河猴或狒狒的血单核细胞产生前体内。 NHP DCREG在存在的抗炎因子存在下，赋予稳定性和抗成熟的抗性，颠覆占性T细胞应答。当移植前注入恒河肾同种异体移植受体时，它们安全地延长MHC匹配的移植物存活，与抗助剂免疫反应性的衰减相关。在这一简明审查中，我们描述了NHP DCREG的性质，并讨论了它们对T细胞应答，同种心作用和器官移植存活的影响。

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