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首页> 外文期刊>Cellular immunology >Lasting effects of an impairment of Th1-like immune response in gamma-irradiated mice: A resemblance between irradiated mice and aged mice.
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Lasting effects of an impairment of Th1-like immune response in gamma-irradiated mice: A resemblance between irradiated mice and aged mice.

机译：γ-辐照老鼠中Th1样免疫应答损伤的持续效果：辐照小鼠与老年小鼠之间的相似性。

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摘要

Although one of the several chronic effects of ionizing radiation is aging, there are no experimental data on radiation-induced immunological aging. The most interesting change in aging was a helper T (Th) 1/Th2 imbalance. We investigated chronic effect on immune responses after ionizing radiation and its effects in irradiated mice were compared with those of aged mice. The 2-month-old mice received a whole-body irradiation of 5Gy. At 6months after irradiation, we compared the immune functions of the irradiated mice with those of normal mice of the same age and with those of older. Interferon (IFN)-gamma and antigen-specific immunoglobulin (Ig)G2a level were lower in the irradiated mice than in normal mice of same age, showing similar levels to those of old normal mice. In contrast, interleukin (IL)-4 and IL-5 and antigen-specific IgG1 level were increased in irradiated mice when compared with the same aged-normal mice. Next, we investigated the low expression of IL-12p70, IL-12 receptors and IL-18 receptors in irradiated and old mice. Also, the decrease of natural killer cell activity was intensified in the irradiated mice, showing lower than values to those of old mice. Interestingly, in irradiated mice, the absolute numbers and the percentages of natural killer (NK) cells was extremely decreased. But the absolute numbers of Th cells and cytotoxic T (Tc) cells in old mice were significantly decreased. In conclusion, an immunological imbalance by the whole-body irradiation of 5Gy induces to persist in the long term, resulting in the similar results with aging. Our results suggest that the downregulation of the Th1-like immune response shown in old mice rapidly occurred through exposure of ionizing radiation.
机译：虽然电离辐射的几种慢性效应之一是老化，但没有关于辐射诱导的免疫老化的实验数据。老化最有趣的变化是辅助T（th）1 / th2不平衡。我们研究了在电离辐射后对免疫反应的慢性效应，并将其在辐照小鼠中的作用与老年小鼠进行比较。 2个月大的小鼠接受了整体辐照5Gy。在照射后6个月，我们将辐照小鼠与相同年龄的正常小鼠和年龄较大的小鼠的免疫功能进行了比较。干扰素（IFN）-Gamma和抗原特异性免疫球蛋白（Ig）G2A水平在辐照小鼠中低于相同年龄的正常小鼠，显示出与旧正常小鼠的小鼠类似的水平。相比之下，与相同的亮态正常小鼠相比，在照射小鼠中增加了白细胞介素（IL）-4和IL-5和抗原特异性IgG1水平。接下来，我们研究了辐照和老小鼠中IL-12P70，IL-12受体和IL-18受体的低表达。此外，在照射的小鼠中加剧了天然杀手细胞活性的降低，显示出低于旧小鼠的小鼠的值。有趣的是，在辐照的小鼠中，绝对数量和天然杀伤剂（NK）细胞的百分比非常减少。但是旧小鼠中的Th细胞和细胞毒性T（Tc）细胞的绝对数量显着降低。总之，5Gy的全身照射的免疫不平衡诱导长期持续存在，导致衰老的类似结果。我们的研究结果表明，通过暴露电离辐射迅速发生旧小鼠的Th1样免疫反应的下调。

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  • 来源
    《Cellular immunology》 |2011年第1期|共8页
  • 作者

    Park HR; Jo SK;

  • 作者单位

    Radiation Biotechnology Research Division Advanced Radiation Technology Institute Jeongeup Campus of Korea Atomic Energy Research Institute (KAERI) 1266 Sinjeong-dong Jeongeup-si Jeonbuk 580-185 Republic of Korea.;

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  • 正文语种 eng
  • 中图分类 细胞生物学;
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