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首页> 外文期刊>Cellular immunology >Immunomodulatory effects of bone marrow mesenchymal stem cells overexpressing heme oxygenase-1: Protective effects on acute rejection following reduced-size liver transplantation in a rat model
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Immunomodulatory effects of bone marrow mesenchymal stem cells overexpressing heme oxygenase-1: Protective effects on acute rejection following reduced-size liver transplantation in a rat model

机译：骨髓间充质干细胞过表达血红素氧酶-1的免疫调节作用：对大鼠模型急性排斥急性排斥反应的保护作用

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摘要

Here we explore the T-lymphocyte suppressive and immunomodulatory effects of bone marrow mesenchymal stem cells (BMMSCs) overexpressing heme oxygenase-1 (HO-1) on acute rejection following reduced-size liver transplantation (RLT) in a rat model. The proliferation activity, cell cycle progression, secretion of proinflammatory cytokines, expression of CD25 and CD71 in lymphocytes, and activity of NK cells were found to be significantly lowered, and the proportion of regulatory T cells (Tregs) was found to be increased relative to BMMSCs when Adv-HO-1 /BMMSCs were co-cultured with Con A ex vivo; secretion of anti-inflammatory cytokines was significantly higher. When treated with saline, BMMSCs or AdvHO-1 /BMMSCs, post-transplantation rats receiving Adv-HO-1 /BMMSCs showed better median survival time, lower rejection activity index, higher anti-inflammatory cytokine levels, lower proinflammatory cytokine levels, more peripheral Tregs, and lower natural killer cell viability. These results suggest that HO-1 enhanced and prolonged the effects of BMMSCs on acute rejection following RLT, with immunomodulatory effects in which adaptive and innate immunity, as well as paracrine signaling, may play important roles. (C) 2016 Elsevier Inc. All rights reserved.
机译：在这里，我们探讨骨髓间充质干细胞（BMMSCs）过表达血红素氧酶-1（HO-1）在大鼠模型中减少肝移植（RLT）的急性排斥反应的T淋巴细胞抑制和免疫调节作用。发现增殖活性，细胞周期进展，促炎细胞因子的分泌，CD25和CD71在淋巴细胞中的表达，以及NK细胞的活性显着降低，发现调节T细胞（Tregs）的比例相对于BMMSCS当ADV-HO-1 / BMMSCS与锥体均匀培养时;抗炎细胞因子的分泌显着高。当用盐水处理，BMMSCs或ADVHO-1 / BMMSCs，接受ADV-HO-1 / BMMSC的后移植后大鼠表现出更好的中值存活时间，降低排斥活动指数，更高的抗炎细胞因子水平，更低的促炎细胞因子水平，更周围的Tregs和较低的自然杀伤细胞活力。这些结果表明，HO-1增强并延长了BMMSCs对RLT后急性排斥反应的影响，具有免疫调节效果，其中适应性和先天免疫以及旁静脉信号传导可能起到重要的作用。 （c）2016年Elsevier Inc.保留所有权利。

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  • 来源
    《Cellular immunology》 |2017年第2017期|共15页
  • 作者

    Shen Zhong-Yang; Wu Bin; Liu Tao; Yang Yang; Yin Ming-Li; Zheng Wei-Ping; Zhang Bo-Ya; Song Hong-Li;

  • 作者单位

    Tianjin First Cent Hosp Dept Organ Transplantat Tianjin 300192 Peoples R China;

    Tianjin First Cent Hosp Dept Organ Transplantat Tianjin 300192 Peoples R China;

    Tianjin First Cent Hosp Dept Organ Transplantat Tianjin 300192 Peoples R China;

    Tianjin First Cent Hosp Dept Organ Transplantat Tianjin 300192 Peoples R China;

    Tianjin First Cent Hosp Dept Organ Transplantat Tianjin 300192 Peoples R China;

    Tianjin First Cent Hosp Dept Organ Transplantat Tianjin 300192 Peoples R China;

    Minist Hlth Key Lab Emergency &

    Care Med Tianjin 300192 Peoples R China;

    Tianjin First Cent Hosp Dept Organ Transplantat Tianjin 300192 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    BM MSCS; HO-1; Liver transplantation; Rejection; lmmunomodulation;

    机译：BM MSCs;HO-1;肝移植;排斥;LMMUNOMODULACULAULE;

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