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The paradox of Th17 cell functions in tumor immunity

机译：Th17细胞悖论在肿瘤免疫中的悖论

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Highlights ? Th17 cells produce high level of IL-17?that have close association with tumorigenesis. ? IL-17 cytokines are double-edged agents and depending on type of cancer can be as anti- and pro-tumor cytokines. ? Th17 cells may mediate protective anti-tumor immunity. ? IL-17A is well-known to stimulate angiogenesis in tumor context. ? Th17 cells and Th17-related cytokines have been exposed to have both anti-tumorigenic and pro-tumorigenic roles. Abstract Immune system acts as a host defensive mechanism protecting against attacking pathogens and transformed cells, including cancer cells. Th17 cells are a specific subset of T helper lymphocytes determined by high secretion of IL-17 and other inflammatory cytokines. Th17 cells increase tumor progression by activating angiogenesis and immunosuppressive activities. They can also mediate antitumor immune responses through recruiting immune cells into tumors, stimulating effector CD8+?T cells, or surprisingly by altering toward Th1 phenotype and producing IFN-γ, so Th17 cells are supposed as a double-edged sword in cancer. A comprehensive approach to indicating the activity of Th17 cells in tumor progression could help in the planning of new therapeutic approaches specially targeting Th17 cells in cancer.
机译：强调 ？ Th17细胞产生高水平的IL-17？与肿瘤发生密切相关。还IL-17细胞因子是双刃代理，具体取决于癌症的类型可以是抗血糖细胞因子。还Th17细胞可能介导保护抗肿瘤免疫。还众所周知，IL-17A可刺激肿瘤背景下的血管生成。还将Th17细胞和Th17相关的细胞因子暴露于抗致瘤和促致致瘤的作用。摘要免疫系统作为保护侵害攻击病原体和转化细胞，包括癌细胞的宿主防御机制。 Th17细胞是由IL-17和其他炎性细胞因子的高分泌物确定的T辅助淋巴细胞的特定子集。 Th17细胞通过激活血管生成和免疫抑制活性增加肿瘤进展。它们还可以通过将免疫细胞募集到肿瘤中，刺激效应CD8 +ΔT细胞，或者通过改变Th1表型并产生IFN-γ来介导抗肿瘤免疫反应，或者令人惊讶的是，因此Th17细胞被认为是癌症中的双刃剑。表明肿瘤进展中Th17细胞活性的综合方法可以有助于在癌症中特别针对Th17细胞的新治疗方法的规划。

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