Alteration of CCR6(+) CD95(+) CD4(+) naive T cells in HIV-1 infected patients: Implication for clinical practice

Sun Hong; Geng Wenqing; Cui Hualu; Liang Guoxin; Fu Yajing; Zhang Zining; Jiang Yongjun; Ding Haibo; Xu Junjie; Shang Hong

首页> 外文期刊>Cellular immunology >Alteration of CCR6(+) CD95(+) CD4(+) naive T cells in HIV-1 infected patients: Implication for clinical practice

【24h】

Alteration of CCR6(+) CD95(+) CD4(+) naive T cells in HIV-1 infected patients: Implication for clinical practice

机译：HIV-1感染患者中CCR6（+）CD95（+）CD4（+）幼稚T细胞的改变：临床实践的含义

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The profound deficiency of Th17 cells contributes to HIV disease progression. The mechanisms of their perturbation remain unclear. Recently, CCR6(+) CD95(+) CD4(+) naive T cells (CCR6(+) CD95(+) CD4(+) T-NA), identified as pre-committed Th17 precursors, were recognized as a subpopulation of CD4(+) T cells with stem cell properties. Following phenotypical identification, we evaluated their level in patients during chronic HIV infection and following antiretroviral therapy (ART) using flow cytometry. The levels of CCR6(+) CD95(+) CD4(+) T-NA were decreased during chronic HIV infection and correlated with CD4(+) T cell counts. Immunological responders harbored higher frequency of CCR6(+) CD95(+) CD4(+) T-NA, which was associated with CD4/CD8 T cell ratio. Immunological non-responders with lower frequency of CCR6(+) CD95(+) CD4(+) T-NA failed to exhibit a correlation between CCR6(+) CD95(+) CD4(+) T-NA and CCR6(+) CD95(+) CD4(+) T-CM, and displayed elevated ratio of CCR6(+) CD95(+) CD4(+) T-CM/T-NA. The number of CCR6(+) CD95(+) CD4(+) T-NA was increased following early ART. These findings shed light on the importance of targeting pre-committed Th17 precursors that enhance immune reconstitution.

机译：Th17细胞的深切缺乏有助于艾滋病毒疾病进展。他们的扰动的机制仍然尚不清楚。最近，CCR6（+）CD95（+）CD4（+）纯T细胞（CCR6（+）CD95（+）CD4（+）T-NA）被鉴定为预先犯于预先犯的TH17前体，被认为是CD4的亚群（+）具有干细胞性质的T细胞。在表型鉴定之后，我们在慢性艾滋病毒感染和使用流式细胞术后的抗逆转录病毒治疗期间评估了它们的水平。在慢性艾滋病毒感染期间降低CCR6（+）CD95（+）CD4（+）T-Na的水平，与CD4（+）T细胞计数相关。免疫响应者患有较高频率的CCR6（+）CD45（+）CD4（+）T-NA，其与CD4 / CD8 T细胞比相关。 CCR6（+）CD4（+）CD4（+）T-NA频率较低的免疫非响应剂未能表现出CCR6（+）CD95（+）CD4（+）T-Na和CCR6（+）CD95之间的相关性（+）CD4（+）T-cm，显示CCR6（+）CD95（+）CD4（+）T-cm / T-Na的升高。早期领域的CCR6（+）CD95（+）CD4（+）CD4（+）T-NA的数量增加。这些发现阐明了靶向预先犯下的Th17前体的重要性，这些前体增强免疫重建。

著录项

来源
《Cellular immunology》 |2018年第2018期|共7页
作者
Sun Hong; Geng Wenqing; Cui Hualu; Liang Guoxin; Fu Yajing; Zhang Zining; Jiang Yongjun; Ding Haibo; Xu Junjie; Shang Hong;
展开▼
作者单位

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

China Med Univ Affiliated Hosp 1 Dept Lab Med Key Lab AIDS Immunol Natl Hlth &

Family Planning;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
HIV; CCR6(+) CD95(+) CD4(+) T-NA; T-SCM; Immune reconstitution;

机译：HIV;CCR6（+）CD95（+）CD4（+）T-NA;T-SCM;免疫重建;

相似文献

外文文献
中文文献
专利

1. Alteration of CCR6(+) CD95(+) CD4(+) naive T cells in HIV-1 infected patients: Implication for clinical practice [J] . Sun Hong, Geng Wenqing, Cui Hualu, Cellular immunology . 2018,第期

机译：HIV-1感染患者中CCR6（+）CD95（+）CD4（+）幼稚T细胞的改变：临床实践的含义
2. Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications. [J] . Negredo E, Massanella M, Puig J, Clinical infectious diseases . 2010,第9期

机译：在病毒学抑制的HIV感染患者中，最低的CD4 T细胞计数是预测因子，而高的CD4 T细胞固有凋亡是CD4 T细胞恢复不良的最终机制：临床意义。
3. Nadir CD4 T Cell Count as Predictor and High CD4 T Cell Intrinsic Apoptosis as Final Mechanism of Poor CD4 T Cell Recoveryn in Virologically Suppressed HIV-Infected Patients: Clinical Implications [J] . Julià Blanco Clinical Infectious Diseases . 2010,第9期

机译：Nadir CD4 T细胞计数为预测因子，高CD4 T细胞固有凋亡为病毒学抑制的HIV感染患者中CD4 T细胞恢复不良的最终机制：临床意义
4. SVM-enabled prognostic method for clinical decision making: The use of CD4 T-cell level and HIV-1 viral load for guiding treatment initiation and alteration [C] . Kasmiran Khairul A, Zomaya Albert Y, Mazari Ali A, 23rd IEEE International Symposium on Computer-Based Medical Systems . 2010

机译：支持SVM的临床决策预后方法：使用CD4 T细胞水平和HIV-1病毒载量指导治疗的开始和改变
5. IgE anti-HIV-1 in serum of HIV-1 infected children inhibits HIV-1 production in vitro and IgE mediates cytotoxicity against lymphoma cells expressing HIV-1 and peripheral blood mononuclear cells from an HIV-1 seropositive patient [D] . Bluth, Martin Heath. 1997

机译：HIV-1感染儿童血清中的IgE抗HIV-1抑制了HIV-1的体外产生，IgE介导了对HIV-1血清反应阳性患者表达HIV-1的淋巴瘤细胞和外周血单核细胞的细胞毒性
6. B Lymphocytes but Not Dendritic Cells Efficiently HIV-1 Trans Infect Naive CD4+ T Cells: Implications for the Viral Reservoir [O] . Abigail Gerberick, Diana C. DeLucia, Paolo Piazza, 2021

机译：B淋巴细胞但不是树突状细胞有效的HIV-1反式感染幼稚CD4 + T细胞：对病毒储层的影响
7. P981Lvot area measurement using gated ct data reclassifies aortic stenosis severity as graded by echocardiographyP982Paradoxical low-flow low-gradient aortic stenosis: an intermediate state between moderate and severe aortic stenosis?P983Can rheumatic significant mitral stenosis be a cause of paradoxical low gradient, low flow, in patients with severe aortic stenosis? an echocardiographic and outcome studyP984Clinical and hemodynamic comparison of isolated versus combined aortic and mitral stenosisP985Echocardiographic end-diastolic velocity in the proximal descending aorta should be interpreted with caution when the ascending aorta is dilated: insights from cardiovascular magnetic resonanceP987Prevalence of atrial mitral regurgitation in patients with severe mitral regurgitationP988Role of 2D/3D echocardiography in the risk stratification of endocardial lead-related tricuspid regurgitation: a single-centre study among?241 patientsP989When TEE is needed in patients with staphylococcus aureus bacteremia for the assessment of risk profile of infective endocarditis?P990Appropriateness criteria to echocardiograms for suspected infective endocarditis: experience of a tertiary referral centerP991Independent predictors of outcome in infective endocarditisP992The role of transesophageal cardiography in clinical course and prognosis of complicated infective endocarditis in critically ill patients: our 15 years experienceP993Left bundle branch block atypical pattern as a prognostic determinant in patients taken to TAVIP994Efficacy of long-term ivabradine therapy in severe systolic chronic heart failure patients with and without type 2 diabetes mellitusP995Relations between left ventricular reverse remodeling and serum markers of extracellular matrix fibrosis in dilated cardiomyopathyP996The healthy left ventricle accommodates an increasing vortex formation time for volume transfer in diastolic filling :Implications for heart failureP997Evolutionary changes of pulmonary artery pressure after left ventricular assist device implantP998Functional correlates and prognostic value of coronary flow velocity reserve by vasodilator stress echocardiography in hypertrophic cardiomyopathyP999Quantification of myocardial performance in patients with non-obstructive versus latent-obstructive hypertrophic cardiomyopathyP1000Lifelong arrhythmic risk stratification in arrhythmogenic right ventricular cardiomyopathy: distribution of events and impact of periodical reassessmentP1001Impact of fibrosis visualized by CMR in vectorcardiogram recordings of patients with suspected arrhythmogenic cardiomyopathyP1002Determinants of the beneficial effect of aldosterone antagonism on exercise capacity in heart failure with reduced ejection fractionP1003Myocardial strain values in patients with acute myocarditis and preserved ejection fraction. A magnetic resonance feature tracking studyP1004Detection of subclinical left ventricular dysfunction by speckle tracking echocardiography in patients with myocarditis without prominent wall motion abnormalitiesP1005Aborted sudden cardiac death patients aged <50 years show only mild alterations on cardiac magnetic resonance imagingP1006Relationships between subepicardial and subendocardial longitudinal strain with late gadolinium enhancement in uncomplicated hypertensive patients [O] . L. Moderato, C. Di Nora, A. Soufiani, 2016

机译：P981LVOT区域测量使用门控CT数据重新分类主动脉狭窄的严重程度，以超声心动图7982分类为分类，如二醇的低流量低梯度主动脉狭窄：中度和严重主动脉狭窄之间的中间状态？P983CAN风湿显着二尖瓣狭窄是矛盾的低梯度，低流量的原因在严重主动脉狭窄的患者中？超声心动图和结合分离的主动脉和二尖瓣术和二尖瓣狭窄的血液动力学比较的超声心动图和血液动力学比较在近期下降主动脉中应当谨慎地解释升高的主动脉：从心血管磁共振的洞察中的心血管磁共振PREValence在严重的患者中的洞察中解释二尖瓣regurgitationP988 rool 2D / 3D超声心动图在内膜内铅相关三尖瓣反流的风险分层：241例患者中的单一学习，在葡萄球菌的患者中需要TEE，用于评估感染性心内炎的风险概况？P990姑息度标准怀疑感染心内膜炎的超声心动图：第三节推荐中心的经验，感染endocardisp992在感染性Endocardisap999中的临床过程中的作用和复杂感染的预后的作用生病患者的心内膜炎：我们的15年经验训练束分支块的非典型模式作为患者的预后决定因素，以TaviP994患者在严重的收缩期慢性心力衰竭患者中患者，无型糖尿病患者左心室反向重塑和血清基质纤维化的血清标志物在扩张心肌脑肿瘤中，健康的左心室容纳舒张填充中体积转移的增加的涡旋形成时间：对左心室辅助装置Implantp998函数相关和冠状动脉速率储备的肺动脉压的肺动脉压的影响。血管扩张器应力超声心动图在肥厚性心肌病型499中，非阻塞性患者心肌表现与潜在阻塞性肥厚性心肌病的患者患者患者患者患者血小板治疗1000Lifelong心律失常风险Strati心律病学右心室心肌病的发动机：CMR患者血管瘤术治疗患者血管动脉瘤患者血管诊断患者血管心目记录中CMR的纤维化术治疗的事件和影响患有急性心肌炎和保存的喷射分数。磁共振特征跟踪STOPYP1004DETTECTECTECTET通过突出壁运动患者的斑点左心室功能障碍的亚临床左心室功能障碍，没有突出的壁运动异常，P1005aborted突发的心脏死亡患者<50岁的突然性心脏死亡患者只显示心脏磁共振术中的轻度改变，钆和肾外腺纵向应变之间的心脏磁共振成像P1006相关性简单的高血压患者增强

Alteration of CCR6(+) CD95(+) CD4(+) naive T cells in HIV-1 infected patients: Implication for clinical practice

摘要

著录项

相似文献

相关主题

期刊订阅